Protein Domain : IPR000669

Type:  Family Name:  Mannitol dehydrogenase
Description:  Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates []. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [].Several dehydrogenases have been shown [] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase () (gene mtlD), mannitol 2-dehydrogenase () (gene mtlK); mannonate oxidoreductase () (fructuronate reductase) (gene uxuB); Escherichia colihypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w. Short Name:  Mannitol_DH
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1 Child Features

DB identifier Type Name
IPR023028 Family Mannitol-1-phosphate 5-dehydrogenase

3 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR013131 Domain Mannitol dehydrogenase, N-terminal
IPR023027 Conserved_site Mannitol dehydrogenase, conserved site

1 Cross References

Identifier
PR00084

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003824 IPR000669
GO:0008152 IPR000669
GO:0055114 IPR000669

3 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR000669
GO:0008152 IPR000669
GO:0055114 IPR000669

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
62889 C1FJR8 PAC:27399968 Micromonas sp RCC299 634  
Araha.11756s0241.1.p PAC:28856458 Arabidopsis halleri 386  
Brdisv1BdTR11G1006512m.p PAC:34614623 Brachypodium distachyon BdTR11g 388  
Brdisv1BdTR11A1037380m.p PAC:35684561 Brachypodium distachyon BdTR11a 523  
Nycol.A03562.1.p PAC:44495327 Nymphaea colorata 370  
36037.m000014 B9TL38 PAC:16826851 Ricinus communis 315  
36037.m000014 B9TL38 PAC:16826851 Ricinus communis 315  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1322373
            8254318