Protein Domain : IPR023028

Type:  Family Name:  Mannitol-1-phosphate 5-dehydrogenase
Description:  Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates []. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [].Several dehydrogenases have been shown [] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase () (gene mtlD), mannitol 2-dehydrogenase () (gene mtlK); mannonate oxidoreductase () (fructuronate reductase) (gene uxuB); Escherichia colihypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w.This entry represents the mannitol-1-phosphate 5-dehydrogenase family, which catalyses the reaction D-mannitol-1-phosphate + NAD+=>beta-D-fructose-6-phosphate + H++ NADH Short Name:  Mannitol_1_phos_5_DH
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0 Child Features

1 Contains

DB identifier Type Name
IPR023027 Conserved_site Mannitol dehydrogenase, conserved site

1 Cross References

Identifier
MF_00196

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008926 IPR023028
GO:0019594 IPR023028
GO:0055114 IPR023028

3 Ontology Annotations

GO Term Gene Name
GO:0008926 IPR023028
GO:0019594 IPR023028
GO:0055114 IPR023028

1 Parent Features

DB identifier Type Name
IPR000669 Family Mannitol dehydrogenase

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1322373
            8254318