Protein Domain : IPR003967

Type:  Family Name:  Potassium channel, voltage-dependent, ERG
Description:  Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family iscomposed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism,channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in themaintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which hasbeen termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels;the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.The first EAG K+ channel was identified in Drosophila melanogaster(Fruit fly), following a screen for mutations giving rise to behavioural abnormalities. Disruption of the Eag gene caused an ether-induced, leg-shaking behaviour. Subsequent studies have revealed a conserved multi-gene family of EAG-like K+ channels, which are present in human and many other species. Based on the varying functional properties of the channels, the family has been divided into 3 subfamilies: EAG, ELK and ERG. Interestingly, Caenorhabditis elegansappears to lack the ELK type [].The human ether-a-go-go-related gene (HERG), cloned from hippocampus, shares 49% amino acid identity with EAG. It is also found in the heart, where it helps to control K+ efflux []. Mutations in HERG result in the disruption of the repolarising current and the disease LQT2 syndrome, an inheriteddisorder of cardiac repolarisation that predisposes affected individuals to life-threatening arrhythmias []. Short Name:  K_chnl_volt-dep_ERG
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1 Child Features

DB identifier Type Name
IPR030172 Family Potassium voltage-gated channel subfamily H member 2

4 Contains

DB identifier Type Name
IPR018490 Domain Cyclic nucleotide-binding-like
IPR000595 Domain Cyclic nucleotide-binding domain
IPR014710 Domain RmlC-like jelly roll fold
IPR005821 Domain Ion transport domain

1 Cross References

Identifier
PR01470

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005249 IPR003967
GO:0006813 IPR003967
GO:0016020 IPR003967

3 Ontology Annotations

GO Term Gene Name
GO:0005249 IPR003967
GO:0006813 IPR003967
GO:0016020 IPR003967

1 Parent Features

DB identifier Type Name
IPR003938 Family Potassium channel, voltage-dependent, EAG/ELK/ERG

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
AUR62023579-RA PAC:36297782 Chenopodium quinoa 211  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1772658
            1879548
            1373731
            2448635
            2451788
            2555158
            11178249
            10798390
            7604285
            10187793