Protein Domain : IPR018490

Type:  Domain Name:  Cyclic nucleotide-binding-like
Description:  Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [, , ]. The best studied of these proteins is the prokaryotic catabolite gene activator (alsoknown as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain,three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclicnucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domainin their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signaltransduction. Short Name:  cNMP-bd-like
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1 Child Features

DB identifier Type Name
IPR000595 Domain Cyclic nucleotide-binding domain

1 Contains

DB identifier Type Name
IPR018488 Conserved_site Cyclic nucleotide-binding, conserved site

1 Cross References

Identifier
SSF51206

9 Found Ins

DB identifier Type Name
IPR003938 Family Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR012198 Family cAMP-dependent protein kinase regulatory subunit
IPR006916 Family Popeye protein
IPR003967 Family Potassium channel, voltage-dependent, ERG
IPR002374 Family cGMP-dependent kinase
IPR016846 Family Predicted ion channel, cNMP-binding
IPR022299 Family Transcription regulator, NtcA
IPR003949 Family Potassium channel, voltage-dependent, EAG
IPR003950 Family Potassium channel, voltage-dependent, ELK

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR014710 Domain RmlC-like jelly roll fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413445 D8RPH4 PAC:15414563 Selaginella moellendorffii 434  
98922 D8RQF5 PAC:15417410 Selaginella moellendorffii 259  
105805 D8S0D3 PAC:15417860 Selaginella moellendorffii 293  
416791 D8S0F3 PAC:15403235 Selaginella moellendorffii 758  
113786 D8SCK7 PAC:15418666 Selaginella moellendorffii 726  
84488 D8R498 PAC:15417160 Selaginella moellendorffii 685  
266514 D8QPN0 PAC:15408982 Selaginella moellendorffii 632  
74518 D8QQQ1 PAC:15410615 Selaginella moellendorffii 1024  
75049 D8QQR0 PAC:15409701 Selaginella moellendorffii 940  
440463 D8RBZ0 PAC:15404893 Selaginella moellendorffii 1040  
89324 D8RB40 PAC:15408478 Selaginella moellendorffii 663  
408109 D8R779 PAC:15419484 Selaginella moellendorffii 669  
evm.model.supercontig_116.82 PAC:16406343 Carica papaya 791  
evm.model.supercontig_124.35 PAC:16407192 Carica papaya 545  
evm.model.supercontig_14.141 PAC:16408638 Carica papaya 712  
evm.model.supercontig_14.142 PAC:16408639 Carica papaya 702  
evm.model.supercontig_140.41 PAC:16408887 Carica papaya 702  
evm.model.supercontig_2.68 PAC:16412857 Carica papaya 514  
evm.model.supercontig_205.31 PAC:16413252 Carica papaya 194  
evm.model.supercontig_23.37 PAC:16414246 Carica papaya 683  
evm.model.supercontig_29.137 PAC:16416163 Carica papaya 71  
evm.model.supercontig_3.357 PAC:16416654 Carica papaya 825  
evm.model.supercontig_3.60 PAC:16416845 Carica papaya 707  
evm.model.supercontig_30.2 PAC:16416966 Carica papaya 727  
evm.model.supercontig_334.1 PAC:16417780 Carica papaya 877  
evm.model.supercontig_40.28 PAC:16419428 Carica papaya 734  
evm.model.supercontig_46.159 PAC:16420443 Carica papaya 590  
evm.model.supercontig_65.6 PAC:16424470 Carica papaya 716  
evm.model.supercontig_75.8 PAC:16425922 Carica papaya 466  
evm.model.supercontig_91.38 PAC:16428492 Carica papaya 806  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1710853
            14638413
            10550204