Protein Domain : IPR006202

Type:  Domain Name:  Neurotransmitter-gated ion-channel ligand-binding domain
Description:  Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure. Short Name:  Neur_chan_lig-bd
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0 Child Features

1 Contains

DB identifier Type Name
IPR018000 Conserved_site Neurotransmitter-gated ion-channel, conserved site

3 Cross Referencess

Identifier
PF02931
G3DSA:2.70.170.10
SSF63712

28 Found Ins

DB identifier Type Name
IPR006201 Family Neurotransmitter-gated ion-channel
IPR002394 Family Nicotinic acetylcholine receptor
IPR002289 Family Gamma-aminobutyric-acid A receptor, beta subunit
IPR005437 Family Gamma-aminobutyric-acid A receptor, gamma subunit
IPR005438 Family Gamma-aminobutyric-acid A receptor, gamma 1 subunit
IPR005439 Family Gamma-aminobutyric-acid A receptor, gamma 2 subunit
IPR005440 Family Gamma-aminobutyric-acid A receptor, gamma 3 subunit
IPR005435 Family Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR001390 Family Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005436 Family Gamma-aminobutyric-acid A receptor, alpha 6 subunit
IPR005433 Family Gamma-aminobutyric-acid A receptor, alpha 3 subunit
IPR005431 Family Gamma-aminobutyric-acid A receptor, alpha 1 subunit
IPR005432 Family Gamma-aminobutyric-acid A receptor, alpha 2 subunit
IPR015680 Family Glutamate-Gated Chloride Channel
IPR008059 Family Gamma-aminobutyric-acid A receptor, Rho2
IPR008057 Family Gamma-aminobutyric-acid A receptor, Rho
IPR008058 Family Gamma-aminobutyric-acid A receptor, Rho1
IPR008060 Family Glycine receptor beta
IPR008098 Family Gamma-aminobutyric-acid A receptor delta subunit
IPR008129 Family Glycine receptor alpha2
IPR008127 Family Glycine receptor alpha
IPR008128 Family Glycine receptor alpha1
IPR008130 Family Glycine receptor alpha3
IPR008134 Family 5-hydroxytryptamine 3 receptor, B subunit
IPR008132 Family 5-hydroxytryptamine 3 receptor
IPR008133 Family 5-hydroxytryptamine 3 receptor, A subunit
IPR008101 Family Gamma-aminobutyric-acid A receptor theta subunit
IPR008100 Family Gamma-aminobutyric-acid A receptor pi subunit

3 GO Annotations

GO Term Gene Name
GO:0005230 IPR006202
GO:0006810 IPR006202
GO:0016020 IPR006202

3 Ontology Annotations

GO Term Gene Name
GO:0005230 IPR006202
GO:0006810 IPR006202
GO:0016020 IPR006202

0 Parent Features

87 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Lus10013984 PAC:23170101 Linum usitatissimum 316  
59323 C1E8C5 PAC:27402350 Micromonas sp RCC299 420  
Thecc1EG002448t1 A0A061DU96 PAC:27437311 Theobroma cacao 133  
Cre17.g705050.t1.2 A0A2K3CP75 PAC:30782866 Chlamydomonas reinhardtii 792  
Cre17.g706450.t1.1 A0A2K3CPA5 PAC:30782064 Chlamydomonas reinhardtii 1045  
Cre17.g707200.t1.1 A0A2K3CPE0 PAC:30782018 Chlamydomonas reinhardtii 859  
Cre02.g104250.t1.1 A0A2K3E2H7 PAC:30785254 Chlamydomonas reinhardtii 2096  
Medtr5g068180.1 G7KDA5 PAC:31089572 Medicago truncatula 61  
Medtr7g078610.1 G7L5T0 PAC:31079154 Medicago truncatula 93  
Traes_2AL_09A85C194.3 PAC:31735975 Triticum aestivum 217  
Traes_2AL_09A85C194.4 PAC:31735976 Triticum aestivum 168  
Eucgr.J02093.1.p A0A059AH68 PAC:32035153 Eucalyptus grandis 173  
LOC_Os08g43760.1 PAC:33104461 Oryza sativa 237  
Dusal.0368s00007.1.p PAC:33194818 Dunaliella salina 82  
Dusal.0368s00007.2.p PAC:33194819 Dunaliella salina 80  
Brdisv1Bd3-1_r1008321m.p PAC:33310579 Brachypodium distachyon Bd3-1 74  
AUR62044728-RA PAC:36306626 Chenopodium quinoa 773  
Bol019276 PAC:37350242 Brassica oleracea capitata 375  
PGSC0003DMP400004741 PAC:37462427 Solanum tuberosum 206  
Anaoc.0017s0416.3.p PAC:37531017 Anacardium occidentale 373  
evm.model.Scaffold_614.27 PAC:37861680 Coffea arabica 119  
VIT_218s0001g10640.1 PAC:38038820 Vitis vinifera 144  
HORVU3Hr1G069980.9 PAC:38393681 Hordeum vulgare 238  
Vigun11g118700.1.p A0A4D6LHZ2 PAC:39053122 Vigna unguiculata 181  
Myper.0132s0524.1.p PAC:39119596 Myagrum perfoliatum 88  
Roisl.0046s1599.1.p PAC:39195261 Rorippa islandica 199  
Roisl.0209s0636.1.p PAC:39221234 Rorippa islandica 203  
Camar.1620s0008.1.p PAC:39652543 Cakile maritima 438  
Camar.0340s0022.1.p PAC:39637833 Cakile maritima 298  
Camar.3664s0006.1.p PAC:39601483 Cakile maritima 293  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1721053
            1846404
            10026168
            18446614
            15383648
            18760291
            15165736