1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR027277 | Family | Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD |
| Type: | Family | Name: | Nicotinate-nucleotide pyrophosphorylase |
| Description: | Nicotinate-nucleotide pyrophosphorylase (), also known as quinolinate phosphoribosyltransferase (decarboxylating), catalyses the conversion of nicotinate D-ribonucleotide, pyrophosphate and carbon dioxide into pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate. This enzyme is a type II phosphoribosyltransferase which provides the de novosource of nicotinate mononucleotide (NAMN) for NAD biosynthesis in both prokaryotes and eukaryotes [, ].Structural studies have shown that the active form of this enzyme is a homodimer with an unsual fold [, , ]. The N-terminal forms a mixed alpha/beta domain, while the C-terminal region forms a multi-stranded, open alpha/beta barrel. The active site is found at the C-terminal ends of the beta strands of the alpha/beta barrel, and is bordered by the N-terminal domain of the second subunit of the dimer. It contains several conserved charged residues thought to be important determinants of substrate binding and catalysis. | Short Name: | NadC |
| DB identifier | Type | Name |
|---|---|---|
| IPR027277 | Family | Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD |
