| Type: | Family | Name: | Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD |
| Description: | Proteins in this family includes nicotinate-nucleotide pyrophosphorylase () and putative pyrophosphorylase ModD. Nicotinate-nucleotide pyrophosphorylase is a type II phosphoribosyltransferase which provides the de novosource of nicotinate mononucleotide (NAMN) for NAD biosynthesis in both prokaryotes and eukaryotes [, ]. Human quinolinate phosphoribosyltransferase (also known as hQPRTase) is involved in the catabolism of quinolinic acid (QA) []. Elevation of QA levels in the brain has been linked to the pathogenesis of a range of neurodegenerative disorders []. ModD is found with molybdenum transport genes modABC in Rhodobacter capsulatus. However, disruption of modD causes only a 4-fold (rather than 500-fold for modA, modB, modC) change in the external molybdenum concentration required to suppress an alternative nitrogenase []. ModD proteins are highly similar to nicotinate-nucleotide pyrophosphorylase (also called quinolinate phosphoribosyltransferase). Their function is unknown. | Short Name: | NadC/ModD |
