Protein Domain : IPR016208

Type:  Family Name:  Aldehyde oxidase/xanthine dehydrogenase
Description:  This entry includes aldehyde oxidases and xanthine dehydrogenases. They are both molybdenum cofactor (Moco) containing enzymes []. Aldehyde oxicases catalyse the reaction: aldehyde + H(2)O + O(2) = a carboxylic acid + H2O2 It binds 2 2Fe-2S clusters uses FAD and molybdopterin as cofactors. Xanthine has the same co-factors and can be converted from the dehydrogenase form (D) to the oxidase form (O). This can be done irreversibly by proteolysis or reversibly through the oxidation of sulphydryl groups. This enzyme catalyses three reactions: Xanthine + H2O + NAD+= urate + NADHHypoxanthine + H2O + NAD+= xanthine + NADHXanthine + H2O + O2 = urate + H2O2In Arabidopsis thaliana, the molybdenum cofactor sulphurase ABA3 is needed for post-translational activation of aldehyde oxidase and xanthine dehydrogenase. It does this by transferring a sulphfur atom to the desulpho-molybdenum cofactor of these enzymes [, ] Short Name:  Ald_Oxase/xanthine_DH
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1 Child Features

DB identifier Type Name
IPR014313 Family Aldehyde oxidase

8 Contains

DB identifier Type Name
IPR016169 Domain CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
IPR001041 Domain 2Fe-2S ferredoxin-type iron-sulfur binding domain
IPR002888 Domain [2Fe-2S]-binding
IPR002346 Domain Molybdopterin dehydrogenase, FAD-binding
IPR008274 Domain Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
IPR005107 Domain CO dehydrogenase flavoprotein, C-terminal
IPR000674 Domain Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR006058 Binding_site 2Fe-2S ferredoxin, iron-sulphur binding site

1 Cross References

Identifier
PIRSF000127

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005506 IPR016208
GO:0016491 IPR016208
GO:0055114 IPR016208

3 Ontology Annotations

GO Term Gene Name
GO:0005506 IPR016208
GO:0016491 IPR016208
GO:0055114 IPR016208

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
443347 D8S0L6 PAC:15412996 Selaginella moellendorffii 1285  
268099 D8S343 PAC:15411279 Selaginella moellendorffii 1336  
444239 D8S844 PAC:15415133 Selaginella moellendorffii 1326  
evm.model.supercontig_103.92 PAC:16404982 Carica papaya 1364  
evm.model.supercontig_103.95 PAC:16404985 Carica papaya 1301  
29854.m001093 B9RQ18 PAC:16811605 Ricinus communis 1366  
29854.m001100 B9RQ25 PAC:16811612 Ricinus communis 1370  
30169.m006431 B9RIB6 PAC:16821231 Ricinus communis 1366  
Cucsa.143330.1 PAC:16963769 Cucumis sativus 1368  
Cucsa.152810.1 A0A0A0KZ08 PAC:16964590 Cucumis sativus 1364  
Cucsa.152810.3 PAC:16964592 Cucumis sativus 1227  
Cucsa.152820.2 PAC:16964594 Cucumis sativus 1183  
Cucsa.152810.2 PAC:16964591 Cucumis sativus 1332  
Cucsa.152820.1 A0A0A0KWS2 PAC:16964593 Cucumis sativus 1371  
Cucsa.143330.2 PAC:16963770 Cucumis sativus 1161  
orange1.1g000657m A0A067F1T2 PAC:18124154 Citrus sinensis 1370  
orange1.1g000805m A0A067FCW8 PAC:18124156 Citrus sinensis 1276  
orange1.1g000807m A0A067FCW8 PAC:18124157 Citrus sinensis 1276  
orange1.1g001052m A0A067F1N0 PAC:18124158 Citrus sinensis 1172  
orange1.1g000775m A0A067F5A4 PAC:18124155 Citrus sinensis 1291  
orange1.1g000981m A0A067ET42 PAC:18127570 Citrus sinensis 1202  
orange1.1g001024m A0A067EH16 PAC:18127571 Citrus sinensis 1185  
orange1.1g000669m A0A067ETZ1 PAC:18127553 Citrus sinensis 1362  
orange1.1g000629m A0A067ETY7 PAC:18127569 Citrus sinensis 1383  
AT4G34900.1 F4JLI5 PAC:19645925 Arabidopsis thaliana 1353  
AT4G34890.1 Q8GUQ8 PAC:19646904 Arabidopsis thaliana 1361  
AT5G20960.2 Q7G193 PAC:19672075 Arabidopsis thaliana 1368  
AT5G20960.1 Q7G193 PAC:19672074 Arabidopsis thaliana 1368  
AT1G04580.1 Q7G191 PAC:19654411 Arabidopsis thaliana 1337  
Thhalv10024224m V4MLM3 PAC:20195306 Eutrema salsugineum 1358  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17649978
            18258600