Protein Domain : IPR000674

Type:  Domain Name:  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Description:  Aldehyde oxidase () catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase () catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase () activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.The aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain is an evolutionary conserved protein domain [, ]. Short Name:  Ald_Oxase/Xan_DH_a/b
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF01315
SM01008
G3DSA:3.90.1170.50
SSF54665

8 Found Ins

DB identifier Type Name
IPR016208 Family Aldehyde oxidase/xanthine dehydrogenase
IPR014309 Domain Xanthine dehydrogenase, molybdopterin binding subunit
IPR014313 Family Aldehyde oxidase
IPR017697 Family Selenium-dependent xanthine dehydrogenase
IPR017699 Family Probable selenate reductase, molybdenum-binding subunit
IPR012780 Family Carbon-monoxide dehydrogenase, large subunit
IPR017607 Family 4-hydroxybenzoyl-CoA reductase, alpha subunit
IPR017609 Family Xanthine dehydrogenase D subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
96875 D8RLG8 PAC:15410972 Selaginella moellendorffii 1334  
443347 D8S0L6 PAC:15412996 Selaginella moellendorffii 1285  
268099 D8S343 PAC:15411279 Selaginella moellendorffii 1336  
419183 D8S842 PAC:15407351 Selaginella moellendorffii 510  
444239 D8S844 PAC:15415133 Selaginella moellendorffii 1326  
230735 PAC:15416147 Selaginella moellendorffii 1264  
evm.model.supercontig_103.92 PAC:16404982 Carica papaya 1364  
evm.model.supercontig_103.93 PAC:16404983 Carica papaya 914  
evm.model.supercontig_103.95 PAC:16404985 Carica papaya 1301  
evm.model.supercontig_84.69 PAC:16427353 Carica papaya 1136  
29854.m001093 B9RQ18 PAC:16811605 Ricinus communis 1366  
29854.m001095 B9RQ20 PAC:16811607 Ricinus communis 1223  
29854.m001100 B9RQ25 PAC:16811612 Ricinus communis 1370  
30169.m006431 B9RIB6 PAC:16821231 Ricinus communis 1366  
33034.m000028 B9TH49 PAC:16825669 Ricinus communis 90  
47744.m000020 B9TM44 PAC:16828020 Ricinus communis 167  
59748.m000022 B9TN81 PAC:16829284 Ricinus communis 59  
29631.m001038 B9SHB6 PAC:16804120 Ricinus communis 189  
Cucsa.143330.1 PAC:16963769 Cucumis sativus 1368  
Cucsa.152810.1 A0A0A0KZ08 PAC:16964590 Cucumis sativus 1364  
Cucsa.152810.3 PAC:16964592 Cucumis sativus 1227  
Cucsa.152820.2 PAC:16964594 Cucumis sativus 1183  
Cucsa.152810.2 PAC:16964591 Cucumis sativus 1332  
Cucsa.152820.1 A0A0A0KWS2 PAC:16964593 Cucumis sativus 1371  
Cucsa.143330.2 PAC:16963770 Cucumis sativus 1161  
orange1.1g000657m A0A067F1T2 PAC:18124154 Citrus sinensis 1370  
orange1.1g000805m A0A067FCW8 PAC:18124156 Citrus sinensis 1276  
orange1.1g000807m A0A067FCW8 PAC:18124157 Citrus sinensis 1276  
orange1.1g001052m A0A067F1N0 PAC:18124158 Citrus sinensis 1172  
orange1.1g000775m A0A067F5A4 PAC:18124155 Citrus sinensis 1291  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7502041
            10430865