Protein Domain : IPR001754

Type:  Domain Name:  Orotidine 5'-phosphate decarboxylase domain
Description:  Orotidine 5'-phosphate decarboxylase (OMPdecase) [, ] catalyses the last step in the de novobiosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.This entry also includes enzymes such as 3-hexulose-6-phosphate synthase and 3-keto-L-gulonate-6-phosphate decarboxylase . Short Name:  OMPdeCOase_dom
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1 Child Features

DB identifier Type Name
IPR017553 Domain 3-hexulose-6-phosphate synthase

1 Contains

DB identifier Type Name
IPR018089 Active_site Orotidine 5'-phosphate decarboxylase, active site

2 Cross Referencess

Identifier
PF00215
SM00934

4 Found Ins

DB identifier Type Name
IPR014732 Family Orotidine 5'-phosphate decarboxylase
IPR020868 Family Bifunctional enzyme Fae/Hps
IPR017120 Family Bifunctional 3-hexulose-6-phosphate synthase/demethylmenaquinone methyltransferase, predicted
IPR011995 Family Orotidine 5'-phosphate decarboxylase, type 2

2 GO Annotations

GO Term Gene Name
GO:0004590 IPR001754
GO:0006207 IPR001754

2 Ontology Annotations

GO Term Gene Name
GO:0004590 IPR001754
GO:0006207 IPR001754

1 Parent Features

DB identifier Type Name
IPR011060 Domain Ribulose-phosphate binding barrel

703 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
236575 D8TAS2 PAC:15409898 Selaginella moellendorffii 449  
448325 D8T6I1 PAC:15405135 Selaginella moellendorffii 483  
evm.model.supercontig_223.10 PAC:16414010 Carica papaya 325  
30131.m007210 B9RGC1 PAC:16819031 Ricinus communis 370  
Cucsa.317630.1 A0A0A0KNB1 PAC:16977155 Cucumis sativus 480  
AT3G54470.1 Q42586 PAC:19664004 Arabidopsis thaliana 476  
Thhalv10010334m V4L3Z2 PAC:20206757 Eutrema salsugineum 476  
Ciclev10001014m V4SV87 PAC:20788591 Citrus clementina 477  
Ciclev10004916m PAC:20791356 Citrus clementina 467  
Lus10039539 PAC:23165040 Linum usitatissimum 477  
Lus10024166 PAC:23141544 Linum usitatissimum 479  
Potri.001G026300.1 A0A2K2BRD9 PAC:27048258 Populus trichocarpa 509  
Potri.001G026300.3 PAC:27048260 Populus trichocarpa 474  
Potri.001G026300.2 PAC:27048261 Populus trichocarpa 404  
Potri.001G026300.4 PAC:27048259 Populus trichocarpa 485  
Potri.003G198500.1 A0A2K2B9U7 PAC:26999828 Populus trichocarpa 474  
Gorai.013G167000.1 A0A0D2VGF9 PAC:26788924 Gossypium raimondii 473  
Gorai.013G167000.2 A0A0D2W6T9 PAC:26788925 Gossypium raimondii 435  
Gorai.009G432600.1 A0A0D2U139 PAC:26769265 Gossypium raimondii 473  
Gorai.009G432600.2 A0A0D2V1M4 PAC:26769266 Gossypium raimondii 352  
54059 I0YTC7 PAC:27391745 Coccomyxa subellipsoidea C-169 485  
162172 C1N3T4 PAC:27348919 Micromonas pusilla CCMP1545 484  
80764 C1E3T0 PAC:27400483 Micromonas sp RCC299 481  
19418 A4RTZ8 PAC:27413023 Ostreococcus lucimarinus 474  
14493 PAC:27413073 Ostreococcus lucimarinus 465  
Thecc1EG031360t1 A0A061F719 PAC:27444272 Theobroma cacao 484  
Thecc1EG031360t2 A0A061F815 PAC:27444273 Theobroma cacao 473  
Migut.N01834.1.p A0A022RTB9 PAC:28925111 Mimulus guttatus 472  
Migut.O00503.1.p A0A022PXM5 PAC:28948030 Mimulus guttatus 328  
Migut.B01220.2.p A0A022RET2 PAC:28946663 Mimulus guttatus 482  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1730672
            2835631