| Type: | Active_site | Name: | Orotidine 5'-phosphate decarboxylase, active site |
| Description: | Orotidine 5'-phosphate decarboxylase (OMPdecase) [, ] catalyses the last step in the de novobiosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme. | Short Name: | OMPdecase_AS |
