Protein Domain : IPR020868

Type:  Family Name:  Bifunctional enzyme Fae/Hps
Description:  This bifunctional enzyme catalyses the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin and the formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate. Formaldehyde activating enzyme (Fae) was first discovered in methylotrophic bacteria, where it is involved in the oxidation of methanol to CO2 and in formaldehyde detoxification. The genome of Methanosarcina barkericontains both the faeA gene as well as a second gene, faeB-hpsB, which is shown to code for a 42 kDa protein with both Fae activity and hexulose-6-phosphate synthase (Hps) activity []. Short Name:  Fae/Hps
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0 Child Features

4 Contains

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel
IPR011060 Domain Ribulose-phosphate binding barrel
IPR001754 Domain Orotidine 5'-phosphate decarboxylase domain
IPR014826 Domain Formaldehyde-activating enzyme

1 Cross References

Identifier
MF_01268

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016832 IPR020868
GO:0016840 IPR020868
GO:0016051 IPR020868

3 Ontology Annotations

GO Term Gene Name
GO:0016832 IPR020868
GO:0016840 IPR020868
GO:0016051 IPR020868

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16075199