Protein Domain : IPR011761

Type:  Domain Name:  ATP-grasp fold
Description:  The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule []. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example, DD-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination [].The ATP-grasp domain contains three conserved motifs, corresponding to the phosphate binding loop and the Mg(2+) binding site []. The fold is characterised by two alpha-beta subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that formspart of the active site, with regions from other domains also contributing to the active site, even though these other domains are not conserved between the various ATP-grasp enzymes []. Short Name:  ATP-grasp
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8 Child Features

DB identifier Type Name
IPR011095 Domain D-alanine--D-alanine ligase, C-terminal
IPR013650 Domain ATP-grasp fold, succinyl-CoA synthetase-type
IPR003806 Domain ATP-grasp fold, DUF201-type
IPR005479 Domain Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR013651 Domain ATP-grasp fold, RimK-type
IPR020561 Domain Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR004218 Domain Prokaryotic glutathione synthetase, ATP-binding
IPR009720 Domain IMP biosynthesis enzyme PurP, C-terminal

4 Contains

DB identifier Type Name
IPR013815 Domain ATP-grasp fold, subdomain 1
IPR003135 Domain ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR020559 Conserved_site Phosphoribosylglycinamide synthetase, conserved site
IPR000291 Conserved_site D-alanine--D-alanine ligase/VANA/B/C, conserved site

1 Cross References

Identifier
PS50975

10 Found Ins

DB identifier Type Name
IPR005809 Family Succinyl-CoA synthetase, beta subunit
IPR008656 Family Inositol-tetrakisphosphate 1-kinase
IPR005875 Domain Phosphoribosylaminoimidazole carboxylase, ATPase subunit
IPR016301 Family Phosphoribosylaminoimidazole carboxylase
IPR000115 Family Phosphoribosylglycinamide synthetase
IPR006284 Family Glutathione synthetase, prokaryotic
IPR005862 Family Phosphoribosylglycinamide formyltransferase 2
IPR011810 Family Cyanophycin synthetase
IPR017534 Family GNAT-acetyltransferase
IPR006335 Family Glutathione biosynthesis bifunctional protein GshAB

2 GO Annotations

GO Term Gene Name
GO:0005524 IPR011761
GO:0046872 IPR011761

2 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR011761
GO:0046872 IPR011761

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
440891 D8RF71 PAC:15408013 Selaginella moellendorffii 1194  
411783 D8RJ11 PAC:15411077 Selaginella moellendorffii 557  
411767 D8RIZ5 PAC:15411017 Selaginella moellendorffii 541  
411779 D8RJ07 PAC:15411040 Selaginella moellendorffii 636  
232261 D8RSZ8 PAC:15418206 Selaginella moellendorffii 316  
438375 D8QXH7 PAC:15420474 Selaginella moellendorffii 499  
79988 D8QXW8 PAC:15406024 Selaginella moellendorffii 565  
80448 D8QY44 PAC:15405292 Selaginella moellendorffii 437  
180525 D8SKF8 PAC:15414053 Selaginella moellendorffii 857  
121407 D8SNZ6 PAC:15417524 Selaginella moellendorffii 577  
183371 D8SWL6 PAC:15421200 Selaginella moellendorffii 2192  
77392 D8QRV7 PAC:15417976 Selaginella moellendorffii 747  
evm.TU.contig_34215.1 PAC:16430420 Carica papaya 430  
evm.model.supercontig_113.32 PAC:16406042 Carica papaya 537  
evm.model.supercontig_115.27 PAC:16406190 Carica papaya 506  
evm.model.supercontig_160.11 PAC:16410141 Carica papaya 357  
evm.model.supercontig_162.3 PAC:16410252 Carica papaya 525  
evm.model.supercontig_2592.1 PAC:16415024 Carica papaya 361  
evm.model.supercontig_33.102 PAC:16417545 Carica papaya 629  
evm.model.supercontig_66.90 PAC:16424659 Carica papaya 1924  
evm.model.supercontig_81.16 PAC:16426919 Carica papaya 807  
29703.m001477 B9SFG9 PAC:16806173 Ricinus communis 742  
29765.m000735 B9SKC3 PAC:16808204 Ricinus communis 534  
29908.m005991 B9RJG2 PAC:16812814 Ricinus communis 2259  
30073.m002287 B9S244 PAC:16816870 Ricinus communis 343  
30111.m000702 B9SK20 PAC:16817861 Ricinus communis 1197  
30170.m013637 B9R6S4 PAC:16821486 Ricinus communis 355  
30185.m000954 B9S1E2 PAC:16823058 Ricinus communis 541  
54260.m000027 B9TJB8 PAC:16828702 Ricinus communis 263  
29680.m001662 B9S7H9 PAC:16805496 Ricinus communis 629  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7862655
            9416615
            7939684
            8804825