Protein Domain : IPR001048

Type:  Domain Name:  Aspartate/glutamate/uridylate kinase
Description:  This entry contains proteins with various specificities and includes the aspartate, glutamate and uridylate kinase families. In prokaryotes and plants the synthesis of the essential amino acids lysine and threonine is predominantly regulated by feed-back inhibition of aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS). In Escherichia coli, thrA, metLM, and lysC encode aspartokinase isozymes that show feedback inhibition by threonine, methionine, and lysine, respectively []. The lysine-sensitive isoenzyme of aspartate kinase from spinach leaves has a subunit composition of 4 large and 4 small subunits []. In plants although the control of carbon fixation and nitrogen assimilation has been studied in detail, relatively little is known about the regulation of carbon and nitrogen flow into amino acids. The metabolic regulation of expression of an Arabidopsis thalianaaspartate kinase/homoserine dehydrogenase (AK/HSD) gene, which encodes two linked key enzymes in the biosynthetic pathway of aspartate family amino acids has been studied []. The conversion of aspartate into either the storage amino acid asparagine or aspartate family amino acids may be subject to a coordinated, reciprocal metabolic control, and this biochemical branch point is a part of a larger, coordinated regulatory mechanism of nitrogen and carbon storage and utilization. Short Name:  Asp/Glu/Uridylate_kinase
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0 Child Features

2 Contains

DB identifier Type Name
IPR019797 Conserved_site Glutamate 5-kinase, conserved site
IPR018042 Conserved_site Aspartate kinase, conserved site

3 Cross Referencess

Identifier
PF00696
G3DSA:3.40.1160.10
SSF53633

11 Found Ins

DB identifier Type Name
IPR010167 Family Amino-acid N-acetyltransferase (ArgA)
IPR005766 Family Delta l-pyrroline-5-carboxylate synthetase
IPR001341 Domain Aspartate kinase domain
IPR005715 Family Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase
IPR005260 Family Aspartate kinase, monofunctional class
IPR011147 Family Bifunctional aspartokinase/homoserine dehydrogenase I
IPR011529 Family Glutamate 5-kinase
IPR011242 Family Acetylglutamate kinase argB
IPR011241 Family NAGK-NAGSA, bifunctional
IPR011243 Family N-acetylglutamate synthase, animal
IPR011246 Family Bifunctional diaminopimelate decarboxylase/aspartate kinase

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410685 D8RFI6 PAC:15407190 Selaginella moellendorffii 771  
92970 D8RFL8 PAC:15422182 Selaginella moellendorffii 313  
93428 D8RGG8 PAC:15421198 Selaginella moellendorffii 395  
175390 D8RY95 PAC:15419979 Selaginella moellendorffii 590  
80442 D8QWR7 PAC:15405290 Selaginella moellendorffii 860  
142417 D8QZN3 PAC:15412575 Selaginella moellendorffii 468  
130409 D8T2D7 PAC:15421681 Selaginella moellendorffii 392  
130301 D8T2A1 PAC:15420966 Selaginella moellendorffii 261  
125041 D8SUG6 PAC:15403782 Selaginella moellendorffii 502  
89918 D8RBD8 PAC:15413181 Selaginella moellendorffii 558  
77370 D8QSK1 PAC:15417916 Selaginella moellendorffii 345  
evm.model.supercontig_128.55 PAC:16407481 Carica papaya 481  
evm.model.supercontig_21.85 PAC:16413600 Carica papaya 885  
evm.model.supercontig_42.112 PAC:16419693 Carica papaya 338  
evm.model.supercontig_454.3 PAC:16420362 Carica papaya 721  
evm.model.supercontig_5.101 PAC:16421198 Carica papaya 313  
evm.model.supercontig_6.178 PAC:16423351 Carica papaya 343  
evm.model.supercontig_6.7 PAC:16423663 Carica papaya 126  
evm.model.supercontig_6.8 PAC:16423674 Carica papaya 268  
evm.model.supercontig_69.30 PAC:16424899 Carica papaya 590  
29757.m000730 B9SHP2 PAC:16808004 Ricinus communis 920  
29801.m003185 B9RYI2 PAC:16809035 Ricinus communis 361  
29815.m000504 PAC:16809560 Ricinus communis 554  
30131.m006990 B9RGY9 PAC:16818815 Ricinus communis 556  
30136.m001020 B9RU12 PAC:16819148 Ricinus communis 328  
30143.m001194 B9SE11 PAC:16819514 Ricinus communis 732  
30170.m013684 B9R6W9 PAC:16821531 Ricinus communis 94  
30174.m009165 B9RCY5 PAC:16822805 Ricinus communis 337  
29119.m000048 B9T9H8 PAC:16802321 Ricinus communis 257  
28077.m000081 B9T6R4 PAC:16799889 Ricinus communis 491  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9584993
            10220897
            9501134