| Type: | Family | Name: | Bifunctional diaminopimelate decarboxylase/aspartate kinase |
| Description: | This group represents a predicted bifunctional diaminopimelate decarboxylase/aspartate kinase from the Gammaproteobacteria.Bifunctional enzymes permit the direct channelling of intermediates between catalytic centres involved in consecutive reactions in a pathway, offering an efficient means of directing the flow of catalysis and protecting intermediates from degradation []. Both diaminopimelate decarboxylase and aspartate kinase are involved in lysine biosynthesis in bacteria, which can be synthesized from aspartate via the formation of the intermediate diaminopimelate (DAP), a metabolite that is also involved in peptidoglycan formation []. Aspartate kinase catalyses the transfer of a phosphate group from ATP to aspartic acid, while diaminopimelate decarboxylase catalyses the conversion of diaminopimelate to lysine. | Short Name: | DAP_dec_asp_kin |
| DB identifier | Type | Name |
|---|---|---|
| IPR009006 | Domain | Alanine racemase/group IV decarboxylase, C-terminal |
| IPR001048 | Domain | Aspartate/glutamate/uridylate kinase |
| IPR001341 | Domain | Aspartate kinase domain |
| IPR022657 | Conserved_site | Orn/DAP/Arg decarboxylase 2, conserved site |
| IPR022653 | Binding_site | Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site |
| IPR018042 | Conserved_site | Aspartate kinase, conserved site |
