Protein Domain : IPR011147

Type:  Family Name:  Bifunctional aspartokinase/homoserine dehydrogenase I
Description:  Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids - lysine, threonine, methionine and isoleucine - in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential component of bacterial cell wall biosynthesis, and dipicolinic acid, which is involved in sporulation in Gram-positive bacteria. Members of the animal kingdom do not posses this pathway and must therefore acquire these essential amino acids through their diet. Research into improving the metabolic flux through this pathway has the potential to increase the yield of the essential amino acids in important crops, thus improving their nutritional value. Additionally, since the enzymes are not present in animals, inhibitors of them are promising targets for the development of novel antibiotics and herbicides. For more information see [].This entry represents the bifunctional enzyme aspartokinase/homoserine dehydrogenase (AK-HSDH) found in bacteria and plant chloroplasts, which catalyses the first and third steps of the aspartate pathway. Homoserine dehydrogenase () catalyses the conversion of L-homoserine to L-aspartate-4-semialdehyde using NAD(P), while aspartate kinase () catalyses the phosphorylation of L-aspartate to 4-phospho-L-aspartate. There are two genes encoding different isoforms of this bifunctional enzymes; one isoform is threonine-sensitive, while the other is methionine-sensitive [].Bifunctional enzymes that catalyse consecutive reactions offer the advantages of efficient channelling and protection of potentially reactive intermediates. AK-HSDH is unusual in its ability to catalyse two non-consecutive reactions. The enzyme that catalyses the intermediary step, aspartate semialdehyde dehydrogenase, it thought to provide a bridge to channel the intermediates between the non-consecutive reactions of AK-HSDH []. Short Name:  Bifunc_aspartokin/hSer_DH
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0 Child Features

7 Contains

DB identifier Type Name
IPR005106 Domain Aspartate/homoserine dehydrogenase, NAD-binding
IPR001342 Domain Homoserine dehydrogenase, catalytic
IPR001048 Domain Aspartate/glutamate/uridylate kinase
IPR002912 Domain ACT domain
IPR001341 Domain Aspartate kinase domain
IPR019811 Conserved_site Homoserine dehydrogenase, conserved site
IPR018042 Conserved_site Aspartate kinase, conserved site

1 Cross References

Identifier
PIRSF000727

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004072 IPR011147
GO:0004412 IPR011147
GO:0009067 IPR011147
GO:0055114 IPR011147

4 Ontology Annotations

GO Term Gene Name
GO:0004072 IPR011147
GO:0004412 IPR011147
GO:0009067 IPR011147
GO:0055114 IPR011147

0 Parent Features

96 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
44479 I0YMK4 PAC:27394465 Coccomyxa subellipsoidea C-169 845  
16870 A4S2Z7 PAC:27413579 Ostreococcus lucimarinus 810  
AUR62005967-RA PAC:36295667 Chenopodium quinoa 829  
Potri.013G099500.2.p A0A2K1Y3M9 PAC:37234639 Populus trichocarpa 886  
AT4G19710.1 O81852 PAC:37388848 Arabidopsis thaliana 859  
VIT_218s0001g03660.1 PAC:38019067 Vitis vinifera 871  
Cz02g01150.t1 PAC:38247055 Chromochloris zofingiensis 827  
HORVU5Hr1G053950.7 PAC:38436427 Hordeum vulgare 884  
HORVU5Hr1G053950.13 PAC:38436421 Hordeum vulgare 828  
HORVU5Hr1G053950.16 PAC:38436429 Hordeum vulgare 828  
HORVU5Hr1G053950.15 PAC:38436428 Hordeum vulgare 850  
HORVU5Hr1G053950.14 PAC:38436431 Hordeum vulgare 828  
HORVU5Hr1G053950.12 PAC:38436430 Hordeum vulgare 828  
Caamp.1033s0744.1.p PAC:39082873 Caulanthus amplexicaulis 892  
Zm00001d019988_P005 A0A1D6I1E2 PAC:40167190 Zea mays 812  
Zm00001d005535_P005 A0A1D6ENN4 PAC:40189123 Zea mays 828  
OsKitaake08g121300.2.p PAC:40582161 Oryza sativa Kitaake 786  
gene12400-v2.0.a2-hybrid.t2 PAC:40664866 Fragaria vesca 839  
gene12400-v2.0.a2-hybrid.t4 PAC:40664867 Fragaria vesca 791  
Thint.15G0138700.1.p PAC:40738741 Thinopyrum intermedium 828  
Glyma.05G151100.8.p PAC:41146465 Glycine max 792  
Glyma.05G151100.7.p PAC:41146463 Glycine max 858  
Glyma.05G151100.2.p K7KQC9 PAC:41146464 Glycine max 839  
Glyma.05G151100.5.p PAC:41146461 Glycine max 883  
Glyma.05G151100.6.p PAC:41146462 Glycine max 862  
Glyma.05G151100.4.p PAC:41146460 Glycine max 896  
Solyc11g040390.2.1 PAC:41476864 Solanum lycopersicum 819  
Pavir.2NG221500.12.p PAC:41569793 Panicum virgatum 894  
Pavir.2NG221500.16.p PAC:41569797 Panicum virgatum 828  
Pavir.2NG221500.15.p PAC:41569796 Panicum virgatum 841  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11352712
            12435751
            11888290