Protein Domain : IPR026082

Type:  Family Name:  ABC transporter A, ABCA
Description:  Members of ABC transporter subfamily A are full-length transporters [], which consist of a single long polypeptide chain organised into two tandemly arranged halves. Each half contains a membrane-spanning domain (MSD) followed by a cytoplasmic nucleotide binding domain (NBD) []. They have various functions [, , , , ,].For example, ABCA7 plays a role in clearance of apoptotic cells by affecting their phagocytosis []. In the human visual cycle, ABCA4 acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. ABCA4 may also play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery []. It has been suggested that ABCA9 plays a role in monocyte differentiation and lipid homeostasis []. Short Name:  ABC_A
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10 Child Features

DB identifier Type Name
IPR030371 Family ATP-binding cassette subfamily A member 12
IPR030372 Family ATP-binding cassette subfamily A member 8
IPR005951 Family Retinal-specific ATP-binding cassette transporter
IPR026969 Family ATP-binding cassette sub-family A member 3
IPR030365 Family ATP-binding cassette subfamily A member 1
IPR030366 Family ATP-binding cassette subfamily A member 2
IPR030367 Family ATP-binding cassette subfamily A member 5
IPR030368 Family ATP-binding cassette subfamily A member 6
IPR030369 Family ATP-binding cassette subfamily A member 7
IPR030370 Family ATP-binding cassette subfamily A member 9

0 Contains

1 Cross References

Identifier
PTHR19229

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005215 IPR026082
GO:0006810 IPR026082
GO:0016021 IPR026082

3 Ontology Annotations

GO Term Gene Name
GO:0005215 IPR026082
GO:0006810 IPR026082
GO:0016021 IPR026082

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171117 D8RFW2 PAC:15406523 Selaginella moellendorffii 937  
231453 D8RFW1 PAC:15416787 Selaginella moellendorffii 913  
93011 D8RFW6 PAC:15418211 Selaginella moellendorffii 835  
174006 D8RT28 PAC:15414680 Selaginella moellendorffii 254  
268954 D8SPB6 PAC:15418023 Selaginella moellendorffii 810  
446307 D8SQA6 PAC:15421527 Selaginella moellendorffii 1853  
424611 D8SQH2 PAC:15403622 Selaginella moellendorffii 1889  
76005 D8QTE9 PAC:15412595 Selaginella moellendorffii 915  
evm.model.supercontig_107.109 PAC:16405290 Carica papaya 850  
evm.model.supercontig_107.110 PAC:16405292 Carica papaya 970  
evm.model.supercontig_224.7 PAC:16414040 Carica papaya 105  
evm.model.supercontig_224.6 PAC:16414039 Carica papaya 287  
evm.model.supercontig_224.8 PAC:16414041 Carica papaya 1391  
evm.model.supercontig_388.1 PAC:16418976 Carica papaya 740  
evm.model.supercontig_388.2 PAC:16418977 Carica papaya 934  
30006.m000286 B9SU42 PAC:16815551 Ricinus communis 1722  
30147.m014092 B9R966 PAC:16820106 Ricinus communis 952  
30147.m014094 B9R968 PAC:16820108 Ricinus communis 902  
30147.m014095 B9R969 PAC:16820109 Ricinus communis 984  
Cucsa.097870.1 PAC:16958219 Cucumis sativus 930  
Cucsa.164320.1 PAC:16965872 Cucumis sativus 174  
Cucsa.164330.1 PAC:16965873 Cucumis sativus 76  
Cucsa.164340.1 PAC:16965874 Cucumis sativus 896  
Cucsa.197580.1 A0A0A0LS95 PAC:16968461 Cucumis sativus 947  
Cucsa.197570.1 PAC:16968460 Cucumis sativus 985  
orange1.1g046109m A0A067D4H6 PAC:18105172 Citrus sinensis 155  
orange1.1g030006m A0A067DA54 PAC:18100689 Citrus sinensis 184  
orange1.1g002236m A0A067GBR4 PAC:18118921 Citrus sinensis 949  
orange1.1g009374m A0A067G8U4 PAC:18118596 Citrus sinensis 536  
orange1.1g010435m A0A067G913 PAC:18118597 Citrus sinensis 510  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11320094
            14592415
            12917409
            12925201
            14570867
            15550377
            16908670
            10075733
            12150964
            23103747