Protein Domain : IPR001478

Type:  Domain Name:  PDZ domain
Description:  PDZ domains (also known as Discs-large homologous regions (DHR) or GLGF)) are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates [, ]. PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences []. In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 microns. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (beta-A to beta-F) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an anti-parallel beta-strand interacts with the beta-B strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the beta-A and beta-B strands. Short Name:  PDZ
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2 Child Features

DB identifier Type Name
IPR029414 Domain Tricorn protease, PDZ domain
IPR024958 Domain GRASP55/65 PDZ-like domain

0 Contains

6 Cross Referencess

Identifier
PF00595
PF13180
PS50106
SM00228
G3DSA:2.30.42.10
SSF50156

28 Found Ins

DB identifier Type Name
IPR004447 Family C-terminal-processing peptidase S41A
IPR004387 Family Peptidase M50, putative membrane-associated zinc metallopeptidase
IPR001940 Family Peptidase S1C
IPR008915 Domain Peptidase M50
IPR012393 Family Tricorn protease
IPR011782 Family Peptidase S1C, Do
IPR011783 Family Peptidase S1C, DegS
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR012153 Family Tyrosine-protein phosphatase non-receptor type 13
IPR016313 Family Disks large 1
IPR015482 Family Syntrophin
IPR014219 Family Peptidase S55, sporulation stage IV, protein B
IPR008339 Family Dishevelled family
IPR008340 Family Dishevelled-1
IPR008341 Family Dishevelled-2
IPR008342 Family Dishevelled-3
IPR015506 Family Dishevelled-related protein
IPR020450 Family Interleukin-16
IPR017673 Family Putative radical SAM enzyme, CHP03279 family
IPR017379 Family Uncharacterised conserved protein UCP038083, PDZ
IPR005419 Family Tight junction protein ZO-2
IPR005417 Family Tight junction protein ZO
IPR005418 Family Tight junction protein ZO-1
IPR005420 Family Tight junction protein ZO-3
IPR017268 Family Tax1-binding protein 3
IPR017300 Family Na(+)/H(+) exchange regulatory cofactor NHERF
IPR015483 Family Gamma 1 syntrophin
IPR015724 Family Serine endopeptidase DegP2

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR001478

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR001478

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430732 D8TAC1 PAC:15422238 Selaginella moellendorffii 315  
165477 D8QUT5 PAC:15413565 Selaginella moellendorffii 1069  
438103 D8QU42 PAC:15418780 Selaginella moellendorffii 227  
78227 D8QVY0 PAC:15419969 Selaginella moellendorffii 255  
79190 D8QV43 PAC:15422181 Selaginella moellendorffii 220  
149210 D8RRH5 PAC:15409127 Selaginella moellendorffii 350  
100929 D8RT64 PAC:15403952 Selaginella moellendorffii 498  
414724 D8RTQ8 PAC:15419634 Selaginella moellendorffii 311  
103058 D8RW90 PAC:15405964 Selaginella moellendorffii 195  
62730 D8QWS1 PAC:15421302 Selaginella moellendorffii 472  
176144 D8S1P5 PAC:15421177 Selaginella moellendorffii 435  
438737 D8QZ27 PAC:15423311 Selaginella moellendorffii 928  
111680 D8S8M7 PAC:15412035 Selaginella moellendorffii 389  
112098 D8S9U8 PAC:15410443 Selaginella moellendorffii 383  
154815 D8SEZ6 PAC:15406273 Selaginella moellendorffii 466  
143443 D8R3W1 PAC:15415587 Selaginella moellendorffii 318  
407040 D8R3Q6 PAC:15415934 Selaginella moellendorffii 372  
439234 D8R2Y2 PAC:15422445 Selaginella moellendorffii 454  
64025 D8QRA5 PAC:15421789 Selaginella moellendorffii 374  
164697 D8QTR3 PAC:15412183 Selaginella moellendorffii 350  
440097 D8RA31 PAC:15402002 Selaginella moellendorffii 919  
159420 D8SYD1 PAC:15417869 Selaginella moellendorffii 352  
90340 D8RDJ7 PAC:15411842 Selaginella moellendorffii 558  
448423 D8T770 PAC:15405926 Selaginella moellendorffii 305  
evm.TU.contig_27975.1 PAC:16429540 Carica papaya 50  
evm.TU.contig_38250.1 PAC:16431158 Carica papaya 77  
evm.model.supercontig_108.26 PAC:16405440 Carica papaya 619  
evm.model.supercontig_119.36 PAC:16406552 Carica papaya 338  
evm.model.supercontig_14.5 PAC:16408797 Carica papaya 450  
evm.model.supercontig_17.120 PAC:16410612 Carica papaya 340  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9204764
            9041651