Protein Domain : IPR011783

Type:  Family Name:  Peptidase S1C, DegS
Description:  Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].This family consists of the periplasmic serine protease DegS (HhoB). They belong to MEROPS peptidase family S1, subfamily S1C (protease Do, clan PA(S)). They are a shorter paralogs of protease Do (HtrA, DegP) and DegQ (HhoA). They are found in Escherichia coliand several of the gammaproteobacteria. DegS contains a trypsin domain and a single copy of PDZ domain (in contrast to DegP with two copies). A critical role of this DegS is to sense stress by detecting misfolded proteins in the periplasm. DegS then cleaves the periplasmic domain of RseA, a transmembrane protein and inhibitor of sigmaE, activating the sigmaE-driven expression of periplasmic proteases/chaperones [, , ]. Short Name:  Pept_S1C_DegS
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0 Child Features

2 Contains

DB identifier Type Name
IPR001478 Domain PDZ domain
IPR001254 Domain Serine proteases, trypsin domain

1 Cross References

Identifier
TIGR02038

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004252 IPR011783
GO:0006508 IPR011783

2 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR011783
GO:0006508 IPR011783

1 Parent Features

DB identifier Type Name
IPR001940 Family Peptidase S1C

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1008665m.p PAC:33619999 Brachypodium distachyon Pangenome 351  
Brdisv1BdTR11A1045266m.p PAC:35697373 Brachypodium distachyon BdTR11a 344  
Brdisv1BdTR11A1040392m.p PAC:35697041 Brachypodium distachyon BdTR11a 351  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8439290
            7845208
            11442831
            12679025
            17360428