Protein Domain : IPR003265

Type:  Domain Name:  HhH-GPD domain
Description:  The HhH-GPD superfamily gets its name from its hallmark helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [, ]. This domain is found in a diverse range of structurally related DNA repair proteins that include: endonuclease III, and DNA glycosylase MutY, an A/G-specific adenine glycosylase. Both of these enzymes have a C-terminal iron-sulphur cluster loop (FCL). The methyl-CPG binding protein (MBD4) also contain a related domain that is a thymine DNA glycosylase []. The family also includes DNA-3-methyladenine glycosylase II , 8-oxoguanine DNA glycosylases and other members of the AlkA family. Short Name:  HhH-GPD_domain
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0 Child Features

4 Contains

DB identifier Type Name
IPR000445 Conserved_site Helix-hairpin-helix motif
IPR003583 Domain Helix-hairpin-helix DNA-binding motif, class 1
IPR004036 Conserved_site Endonuclease III-like, conserved site-2
IPR000035 Conserved_site Alkylbase DNA glycosidase, conserved site

2 Cross Referencess

Identifier
PF00730
SM00478

6 Found Ins

DB identifier Type Name
IPR005759 Family Endonuclease III
IPR005760 Family A/G-specific adenine glycosylase MutY
IPR004577 Family 8-oxoguanine DNA-glycosylase
IPR012092 Family 8-oxoguanine DNA glycosylase/DNA lyase, thermostable
IPR017352 Family Methyl-CpG-binding domain protein 4
IPR017658 Family Conserved hypothetical protein CHP03252, HhH-GPD

1 GO Annotation

GO Term Gene Name
GO:0006284 IPR003265

1 Ontology Annotations

GO Term Gene Name
GO:0006284 IPR003265

1 Parent Features

DB identifier Type Name
IPR011257 Domain DNA glycosylase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
1746 D8S867 PAC:15409358 Selaginella moellendorffii 286  
85281 D8R5T2 PAC:15418542 Selaginella moellendorffii 240  
75917 D8QPT9 PAC:15416488 Selaginella moellendorffii 351  
6975 D8SWP6 PAC:15403143 Selaginella moellendorffii 139  
evm.model.supercontig_15.42 PAC:16409398 Carica papaya 338  
evm.model.supercontig_15.68 PAC:16409426 Carica papaya 497  
evm.model.supercontig_3303.1 PAC:16417752 Carica papaya 343  
evm.model.supercontig_35.61 PAC:16418182 Carica papaya 277  
evm.model.supercontig_6.120 PAC:16423288 Carica papaya 277  
evm.model.supercontig_64.123 PAC:16424195 Carica papaya 355  
evm.model.supercontig_8.9 PAC:16426687 Carica papaya 520  
29991.m000647 B9SN84 PAC:16815264 Ricinus communis 1712  
30005.m001254 B9SF01 PAC:16815486 Ricinus communis 775  
30063.m001426 B9S065 PAC:16816383 Ricinus communis 458  
30147.m014006 B9RB81 PAC:16820021 Ricinus communis 291  
30170.m014051 B9R7V3 PAC:16821888 Ricinus communis 369  
29634.m002129 B9S6F5 PAC:16804270 Ricinus communis 280  
29648.m002007 B9S2W7 PAC:16804848 Ricinus communis 412  
28011.m000079 B9T798 PAC:16799779 Ricinus communis 357  
Cucsa.342430.1 A0A0A0LIY1 PAC:16979369 Cucumis sativus 382  
Cucsa.385370.1 PAC:16982556 Cucumis sativus 1097  
Cucsa.094850.1 PAC:16957794 Cucumis sativus 362  
Cucsa.094850.2 PAC:16957795 Cucumis sativus 357  
Cucsa.098220.1 A0A0A0LTF1 PAC:16958278 Cucumis sativus 307  
Cucsa.127460.1 A0A0A0KM62 PAC:16962049 Cucumis sativus 284  
Cucsa.159110.1 A0A0A0KRW9 PAC:16965210 Cucumis sativus 460  
Cucsa.060560.1 PAC:16954864 Cucumis sativus 393  
Cucsa.349090.1 PAC:16979722 Cucumis sativus 464  
Cucsa.349090.2 PAC:16979723 Cucumis sativus 462  
orange1.1g002448m A0A067DAC5 PAC:18117679 Citrus sinensis 921  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10706276
            10499592
            8805338