Protein Domain : IPR005759

Type:  Family Name:  Endonuclease III
Description:  The spectrum of DNA damage caused by reactive oxygen species includes a wide variety of modifications of purine and pyrimidine bases. Among these modified bases, 7,8-dihydro-8-oxoguanine (8-oxoG) is an important mutagenic lesion. Base excision repair is a critical mechanism for preventing mutations by removing the oxidative lesion from the DNA. Escherichia coliNth protein (endonuclease III) has an 8-oxoG DNA glycosylase/AP lyase activity which removes 8-oxoG preferentially from 8-oxoG/G mispairs. Homo sapiens(Human) hNTH1 protein, a homologue of E. coli Nth protein, has similar DNA glycosylase/AP lyase activity that removes 8-oxoG from 8-oxoG/G mispairs []. Short Name:  Nth
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0 Child Features

4 Contains

DB identifier Type Name
IPR003265 Domain HhH-GPD domain
IPR000445 Conserved_site Helix-hairpin-helix motif
IPR003583 Domain Helix-hairpin-helix DNA-binding motif, class 1
IPR004036 Conserved_site Endonuclease III-like, conserved site-2

3 Cross Referencess

Identifier
PIRSF001435
TIGR01083
MF_00942

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003906 IPR005759
GO:0006284 IPR005759

2 Ontology Annotations

GO Term Gene Name
GO:0003906 IPR005759
GO:0006284 IPR005759

0 Parent Features

41 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
85281 D8R5T2 PAC:15418542 Selaginella moellendorffii 240  
orange1.1g026645m A0A067DKR6 PAC:18115055 Citrus sinensis 235  
orange1.1g026681m A0A067DKR6 PAC:18115056 Citrus sinensis 235  
160767 PAC:27340217 Micromonas pusilla CCMP1545 228  
71484 C1E1T9 PAC:27398538 Micromonas sp RCC299 216  
9118 A4S802 PAC:27419965 Ostreococcus lucimarinus 186  
Araha.2719s0001.1.p PAC:28849720 Arabidopsis halleri 212  
Araha.11756s0340.1.p PAC:28856447 Arabidopsis halleri 189  
Traes_4AL_E9FD810DB.15 PAC:31826075 Triticum aestivum 197  
Brdisv1pangenome1007776m.p PAC:33657689 Brachypodium distachyon Pangenome 212  
Brdisv1BdTR12c1040001m.p PAC:34405123 Brachypodium distachyon BdTR12c 200  
Brdisv1BdTR11A1042831m.p PAC:35689017 Brachypodium distachyon BdTR11a 212  
Brdisv1BdTR11A1042948m.p PAC:35697110 Brachypodium distachyon BdTR11a 331  
Oropetium_20150105_09120A PAC:36001255 Oropetium thomaeum 230  
DCAR_028143 PAC:36061391 Daucus carota 201  
Solyc09g083010.2.1 PAC:36133104 Solanum lycopersicum 239  
Pavir.8KG156100.4.p PAC:37597868 Panicum virgatum 230  
Pavir.8NG231800.1.p PAC:37624581 Panicum virgatum 196  
HORVU7Hr1G039710.5 PAC:38534333 Hordeum vulgare 180  
HORVU7Hr1G039710.10 PAC:38534334 Hordeum vulgare 169  
HORVU7Hr1G039710.8 PAC:38534331 Hordeum vulgare 190  
Isati.0357s0025.2.p PAC:39362016 Isatis tinctoria 233  
Isati.0357s0025.3.p PAC:39362015 Isatis tinctoria 233  
Isati.0357s0025.1.p PAC:39362014 Isatis tinctoria 233  
Isati.3673s0018.1.p PAC:39355462 Isatis tinctoria 233  
Bobra.49_2s0088.1.p PAC:40707759 Botryococcus braunii 165  
Sphfalx16G077600.12.p PAC:41959422 Sphagnum fallax 203  
PvUI111.05G154400.4.p PAC:42834141 Phaseolus vulgaris UI111 230  
PvUI111.05G154400.5.p PAC:42834142 Phaseolus vulgaris UI111 228  
VuTZ30.05G244900.2.p PAC:44162943 Vigna unguiculata TZ30 233  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11328882