Protein Domain : IPR002085

Type:  Family Name:  Alcohol dehydrogenase superfamily, zinc-type
Description:  Alcohol dehydrogenase () (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD:Ethanol + NAD = Acetaldehyde + NADH Currently three structurally and catalytically different types of alcohol dehydrogenases are known:Zinc-containing 'long-chain' alcohol dehydrogenases.Insect-type, or 'short-chain' alcohol dehydrogenases.Iron-containing alcohol dehydrogenases.Zinc-containing ADH's [, ] are dimeric or tetrameric enzymes that bind twoatoms of zinc per subunit. One of the zinc atom is essential for catalytic activity while the other is not. Both zinc atoms are coordinated by eithercysteine or histidine residues; the catalytic zinc is coordinated by two cysteines and one histidine. Zinc-containing ADH's are found in bacteria,mammals, plants, and in fungi. In most species there are more than one isozyme (for example, human have at least six isozymes, yeast have three, etc.). Anumber of other zinc-dependent dehydrogenases are closely related to zinc ADH [] and are included in this family. In addition, this family includes an NADP-dependent quinone oxidoreductase encoded in bacteria by gene qor [, ]. This type of enzymes are also found in yeast and mammals, where in some species, such as rodents, it has been recruited as an eye lens protein and is known as zeta-crystallin []. The sequence of quinone oxidoreductase is distantly related to that other zinc-containing alcohol dehydrogenases and it lacks the zinc-ligand residues. The torpedo fish and mammalian synaptic vesicle membrane protein vat-1 is related to qor. Short Name:  ADH_SF_Zn-type
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17 Child Features

DB identifier Type Name
IPR014187 Family Alcohol dehydrogenase, zinc-binding type 2
IPR014189 Family Quinone oxidoreductase PIG3
IPR014183 Family Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR028632 Family Alcohol dehydrogenase family, zinc-type, class-II subfamily
IPR014182 Family Alcohol dehydrogenase, zinc-binding type 1
IPR004627 Family L-threonine 3-dehydrogenase
IPR014184 Family Formaldehyde dehydrogenase, glutathione-independent
IPR014188 Family Acrylyl-CoA reductase AcuI
IPR014190 Family Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
IPR028635 Family Alcohol dehydrogenase family, zinc-type, class-IV subfamily
IPR028633 Family Alcohol dehydrogenase family, zinc-type, class-V subfamily
IPR017614 Family 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
IPR017743 Family Alcohol dehydrogenase, phosphonate catabolism-associated, putative
IPR017816 Family S-(hydroxymethyl)mycothiol dehydrogenase
IPR023921 Family Alcohol dehydrogenase, zinc-type, actinomycetes
IPR026583 Family Glucose 1-dehydrogenase
IPR005903 Family 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase

3 Contains

DB identifier Type Name
IPR013154 Domain Alcohol dehydrogenase, N-terminal
IPR002364 Conserved_site Quinone oxidoreductase/zeta-crystallin, conserved site
IPR002328 Conserved_site Alcohol dehydrogenase, zinc-type, conserved site

1 Cross References

Identifier
PTHR11695

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008270 IPR002085
GO:0016491 IPR002085
GO:0055114 IPR002085

3 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR002085
GO:0016491 IPR002085
GO:0055114 IPR002085

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410874 D8RG52 PAC:15408766 Selaginella moellendorffii 360  
231517 D8RHI6 PAC:15417457 Selaginella moellendorffii 332  
231648 D8RHV5 PAC:15418308 Selaginella moellendorffii 321  
231782 D8RK93 PAC:15419163 Selaginella moellendorffii 344  
412432 D8RLH1 PAC:15411552 Selaginella moellendorffii 390  
412430 D8RLG9 PAC:15411550 Selaginella moellendorffii 308  
97115 D8RMY3 PAC:15408261 Selaginella moellendorffii 140  
432164 D8TF64 PAC:15401298 Selaginella moellendorffii 297  
438334 D8QW74 PAC:15420365 Selaginella moellendorffii 376  
99539 D8RRB4 PAC:15417293 Selaginella moellendorffii 331  
149351 D8RS04 PAC:15410014 Selaginella moellendorffii 351  
149322 D8RRY0 PAC:15409927 Selaginella moellendorffii 380  
267688 D8RS05 PAC:15412886 Selaginella moellendorffii 351  
101142 D8RT24 PAC:15423130 Selaginella moellendorffii 389  
232268 D8RT18 PAC:15418214 Selaginella moellendorffii 377  
102919 D8RVY3 PAC:15409896 Selaginella moellendorffii 197  
267842 D8RVY7 PAC:15414393 Selaginella moellendorffii 376  
230239 D8QX16 PAC:15412317 Selaginella moellendorffii 349  
270370 D8QWD9 PAC:15419604 Selaginella moellendorffii 338  
405152 D8QWE0 PAC:15410878 Selaginella moellendorffii 620  
438497 D8QYJ4 PAC:15421172 Selaginella moellendorffii 426  
107855 D8S344 PAC:15401491 Selaginella moellendorffii 322  
109935 D8S6X2 PAC:15407964 Selaginella moellendorffii 381  
153092 D8S6G9 PAC:15419777 Selaginella moellendorffii 352  
444096 D8S6F1 PAC:15413795 Selaginella moellendorffii 357  
405891 D8R006 PAC:15416295 Selaginella moellendorffii 137  
110768 D8S843 PAC:15409827 Selaginella moellendorffii 322  
233661 D8SCT2 PAC:15401856 Selaginella moellendorffii 325  
167345 D8R2M0 PAC:15418521 Selaginella moellendorffii 425  
406708 D8R177 PAC:15418251 Selaginella moellendorffii 334  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3622514
            8486156
            8504864
            1593644
            12624201
            14536026