Protein Domain : IPR002328

Type:  Conserved_site Name:  Alcohol dehydrogenase, zinc-type, conserved site
Description:  Alcohol dehydrogenase () (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: Ethanol + NAD = Acetaldehyde + NADH Currently three structurally and catalytically different types of alcohol dehydrogenases are known: Zinc-containing 'long-chain' alcohol dehydrogenases.Insect-type, or 'short-chain' alcohol dehydrogenases.Iron-containing alcohol dehydrogenases.Zinc-containing ADH's [, ] are dimeric or tetrameric enzymes that bind twoatoms of zinc per subunit. One of the zinc atom is essential for catalytic activity while the other is not. Both zinc atoms are coordinated by eithercysteine or histidine residues; the catalytic zinc is coordinated by two cysteines and one histidine. Zinc-containing ADH's are found in bacteria,mammals, plants, and in fungi. In most species there are more than one isozyme (for example, human have at least six isozymes, yeast have three, etc.). A number of other zinc-dependent dehydrogenases are closely related to zincADH [] and are included in this family, includingxylitol dehydrogenase (); sorbitol dehydrogenase (); aryl-alcohol dehydrogenase (); threonine 3-dehydrogenase (); cinnamyl-alcohol dehydrogenase () (CAD); galactitol-1-phosphate dehydrogenase (); and Pseudomonas putida5-exo-alcohol dehydrogenase (). Short Name:  ADH_Zn_CS
Paste the following link

0 Child Features

0 Contains

1 Cross References

Identifier
PS00059

8 Found Ins

DB identifier Type Name
IPR014187 Family Alcohol dehydrogenase, zinc-binding type 2
IPR011032 Domain GroES-like
IPR002085 Family Alcohol dehydrogenase superfamily, zinc-type
IPR013154 Domain Alcohol dehydrogenase, N-terminal
IPR014183 Family Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR004627 Family L-threonine 3-dehydrogenase
IPR014184 Family Formaldehyde dehydrogenase, glutathione-independent
IPR017816 Family S-(hydroxymethyl)mycothiol dehydrogenase

3 GO Annotations

GO Term Gene Name
GO:0008270 IPR002328
GO:0016491 IPR002328
GO:0055114 IPR002328

3 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR002328
GO:0016491 IPR002328
GO:0055114 IPR002328

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3622514
            8504864
            1593644