Protein Domain : IPR003959

Type:  Domain Name:  ATPase, AAA-type, core
Description:  AAA ATPases (ATPases Associated with diverse cellular Activities) form a large protein family and play a number of roles in the cell including cell-cycle regulation, protein proteolysis and disaggregation, organelle biogenesis and intracellular transport. Some of them function as molecular chaperones, subunits of proteolytic complexes or independent proteases (FtsH, Lon). They also act as DNA helicases and transcription factors [].AAA ATPases belong to the AAA+ superfamily of ringshaped P-loop NTPases, which act via the energy-dependent unfolding of macromolecules [, ]. There are six major clades of AAA domains (proteasome subunits, metalloproteases, domains D1 and D2 of ATPases with two AAA domains, the MSP1/katanin/spastin group and BCS1 and it homologues), as well as a number of deeply branching minor clades [].They assemble into oligomeric assemblies (often hexamers) that form a ring-shaped structure with a central pore. These proteins produce a molecular motor that couples ATP binding and hydrolysis to changes in conformational states that act upon a target substrate, either translocating or remodelling it [].They are found in all living organisms and share the common feature of the presence of a highly conserved AAA domain called the AAA module. This domain is responsible for ATP binding and hydrolysis. It contains 200-250 residues, among them there are two classical motifs, Walker A (GX4GKT) and Walker B (HyDE) [].The functional variety seen between AAA ATPases is in part due to their extensive number of accessory domains and factors, and to their variable organisation within oligomeric assemblies, in addition to changes in key functional residues within the ATPase domain itself. Short Name:  ATPase_AAA_core
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0 Child Features

2 Contains

DB identifier Type Name
IPR018368 Conserved_site ClpA/B, conserved site 1
IPR003960 Conserved_site ATPase, AAA-type, conserved site

3 Cross Referencess

Identifier
PF00004
PF07724
PF13304

16 Found Ins

DB identifier Type Name
IPR000641 Family CbxX/CfqX
IPR001270 Family ClpA/B family
IPR017730 Family Chaperonin ClpB
IPR016314 Family Cell division protein Cdc6/18
IPR004815 Family Lon protease, bacterial/eukaryotic-type
IPR012178 Family Replication factor C subunit 1
IPR012763 Family DNA polymerase III, subunit gamma/ tau
IPR000470 Family CbxX/CfqX, monofunctional
IPR004605 Family DNA helicase, Holliday junction RuvB type
IPR013461 Family ATP-dependent Clp protease ATP-binding subunit ClpA
IPR017729 Family Type VI secretion system, ATPase ClpV1
IPR014251 Family Sporulation protease LonB
IPR014252 Family Sporulation protease LonC
IPR014232 Family Sporulation stage V, protein K
IPR022482 Family Proteasome ATPase
IPR017179 Family Spastin

1 GO Annotation

GO Term Gene Name
GO:0005524 IPR003959

1 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR003959

0 Parent Features

37718 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
146742 D8RFQ9 PAC:15404156 Selaginella moellendorffii 428  
171164 D8RG14 PAC:15406646 Selaginella moellendorffii 398  
231444 D8RFU2 PAC:15416761 Selaginella moellendorffii 411  
23739 D8RF32 PAC:15417862 Selaginella moellendorffii 229  
410877 D8RG55 PAC:15408768 Selaginella moellendorffii 736  
236550 D8TAF4 PAC:15409848 Selaginella moellendorffii 320  
231598 D8RGX8 PAC:15417669 Selaginella moellendorffii 865  
411212 D8RGX6 PAC:15406919 Selaginella moellendorffii 740  
411118 D8RGM6 PAC:15406211 Selaginella moellendorffii 1060  
441130 PAC:15405501 Selaginella moellendorffii 395  
137147 D8TCZ5 PAC:15417735 Selaginella moellendorffii 729  
147913 D8RKM5 PAC:15408578 Selaginella moellendorffii 864  
18983 D8RL91 PAC:15404490 Selaginella moellendorffii 55  
412710 D8RL86 PAC:15413851 Selaginella moellendorffii 1781  
412715 D8RL92 PAC:15413860 Selaginella moellendorffii 194  
441722 D8RL97 PAC:15410157 Selaginella moellendorffii 1700  
441720 D8RL81 PAC:15410156 Selaginella moellendorffii 1687  
173081 D8RP37 PAC:15411872 Selaginella moellendorffii 547  
98264 D8RP70 PAC:15412163 Selaginella moellendorffii 570  
413949 D8RR54 PAC:15418301 Selaginella moellendorffii 155  
51018 D8RR02 PAC:15405833 Selaginella moellendorffii 698  
174539 D8RV14 PAC:15418459 Selaginella moellendorffii 885  
415967 D8RXN6 PAC:15401853 Selaginella moellendorffii 153  
415966 D8RXN5 PAC:15401852 Selaginella moellendorffii 288  
141788 D8QWE3 PAC:15412071 Selaginella moellendorffii 879  
30423 D8QXF0 PAC:15414090 Selaginella moellendorffii 928  
405160 D8QWE9 PAC:15410905 Selaginella moellendorffii 432  
79425 D8QWV1 PAC:15402096 Selaginella moellendorffii 451  
104906 D8RZ18 PAC:15415757 Selaginella moellendorffii 403  
106157 D8S0I9 PAC:15415617 Selaginella moellendorffii 310  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15037233
            16919475
            17201069
            16828312