Type: | Family | Name: | Type VI secretion system, ATPase ClpV1 |
Description: | Type VI secretion system (T6SS) appears to be confined to Proteobacteria. It is important for bacterial pathogenesis, but it is also found in non-pathogenic bacteria, suggesting that T6SS involvement is not limited to virulence []. T6SS was identified in Vibrio cholerae [] and Pseudomonas aeruginosa [], and exports Hcp (Haemolysin-Coregulated Protein) and a class of proteins named Vgr (Val-Gly Repeats), whose exact function is still speculative. In addition to Vgr and Hcp proteins, T6SS is characterised by the presence of an AAA+ Clp-like ATPase and of two additional genes icmF and dotU, encoding homologues of T4SS stabilising proteins []. Members of this protein family are ClpV1. The ClpV proteins are most similar to ClpB proteins within the Hsp100/Clp family, but cluster in a separate phylogenetic tree with a remarkable distance to ClpB []. ClpV1 is a key component of the bacterial pathogenicity-associated type VI secretion system. They are required for secretion of Hcp1, probably by providing the energy source for its translocation []. | Short Name: | ATPase_T6SS_ClpV1 |