| Type: | Domain | Name: | BRCT domain |
| Description: | The breast cancer susceptibility gene contains at its C terminus two copies of a conserved domain that was named BRCT for BRCA1 C terminus. This domain ofabout 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control [, , ]. The BRCT domain is notlimited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. Some data [] indicate that the BRCT domain functions as a protein-protein interaction module.The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has recently been determined by X-ray crystallography[]. | Short Name: | BRCT_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR022312 | Family | DNA polymerase family X |
| IPR001726 | Family | DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu |
| IPR012178 | Family | Replication factor C subunit 1 |
| IPR012112 | Family | DNA repair protein, Rev1 |
| IPR001679 | Family | NAD-dependent DNA ligase |
| IPR008288 | Family | NAD+ ADP-ribosyltransferase |
| IPR011364 | Family | Breast cancer type 1 susceptibility protein (BRCA1) |
| IPR016592 | Family | Nibrin |
