Protein Domain : IPR008288

Type:  Family Name:  NAD+ ADP-ribosyltransferase
Description:  NAD+ADP-ribosyltransferase (ADPRT; ), also called poly(ADP-ribose) synthase and poly(ADP-ribose) polymerase (PARP), catalyses the DNA-dependent covalent attachment of ADP-ribose to various nuclear proteins []. It is used by the eukaryotic cell to cope with numerous environmental and endogenous genotoxic agents that cause DNA strand breaks. Accordingly, ADPRT plays a role in many cellular processes, including DNA repair, recombination, cell proliferation and death, as well as genomic stability []. The DNA-binding region of the protein contains a pair of zinc finger domains, which have been shown to bind DNA in a zinc-dependent manner []. ADPRT also contains a BRCT domain involved in cell cycle checkpoint functions responsive to DNA damage [], a catalyic domain and a regulatory domain. Short Name:  NAD_ADPRT
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0 Child Features

6 Contains

DB identifier Type Name
IPR012317 Domain Poly(ADP-ribose) polymerase, catalytic domain
IPR001357 Domain BRCT domain
IPR008893 Domain WGR domain
IPR004102 Domain Poly(ADP-ribose) polymerase, regulatory domain
IPR012982 Domain PADR1
IPR001510 Domain Zinc finger, PARP-type

2 Cross Referencess

Identifier
PTHR15447:SF13
PIRSF000489

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0003677 IPR008288
GO:0003950 IPR008288
GO:0008270 IPR008288
GO:0051287 IPR008288
GO:0006471 IPR008288
GO:0005634 IPR008288

6 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR008288
GO:0003950 IPR008288
GO:0008270 IPR008288
GO:0051287 IPR008288
GO:0006471 IPR008288
GO:0005634 IPR008288

0 Parent Features

211 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Lus10033871 PAC:23172830 Linum usitatissimum 1052  
Eucgr.K03285.1.p A0A059A7U4 PAC:32066353 Eucalyptus grandis 1000  
AUR62024743-RA PAC:36310391 Chenopodium quinoa 953  
Phvul.001G159200.1.p V7CYP7 PAC:37168397 Phaseolus vulgaris 1002  
Potri.002G041300.6.p A0A3N7EIZ3 PAC:37259436 Populus trichocarpa 996  
Potri.002G041300.5.p A0A3N7EIZ3 PAC:37259435 Populus trichocarpa 996  
Potri.002G041300.7.p A0A3N7EIZ3 PAC:37259437 Populus trichocarpa 996  
Potri.002G041300.3.p A0A2K2BD87 PAC:37259438 Populus trichocarpa 948  
Podel.02G043700.1.p PAC:37299708 Populus deltoides WV94 997  
Bol008250 PAC:37344193 Brassica oleracea capitata 965  
AT2G31320.1 Q9ZP54 PAC:37379241 Arabidopsis thaliana 983  
Anaoc.0006s0967.1.p PAC:37485403 Anacardium occidentale 1004  
Anaoc.0006s0967.3.p PAC:37485405 Anacardium occidentale 958  
Anaoc.0006s0967.2.p PAC:37485404 Anacardium occidentale 986  
Pavir.2NG278200.2.p PAC:37587016 Panicum virgatum 979  
Pavir.2KG247300.2.p PAC:37569674 Panicum virgatum 979  
Pavir.2KG247300.1.p PAC:37569673 Panicum virgatum 980  
evm.model.Scaffold_635.322 PAC:37903463 Coffea arabica 986  
Sobic.002G116300.1.p A0A1B6QAL7 PAC:37954323 Sorghum bicolor 979  
VIT_207s0005g03040.1 PAC:38056647 Vitis vinifera 996  
Gohir.A11G129100.1.p PAC:38086384 Gossypium hirsutum 982  
Gohir.D11G134900.1.p PAC:38082193 Gossypium hirsutum 992  
BdiBd21-3.1G0698600.1.p I1H259 PAC:38207130 Brachypodium distachyon Bd21-3 975  
HORVU1Hr1G005980.22 PAC:38478009 Hordeum vulgare 998  
HORVU1Hr1G005980.1 PAC:38478007 Hordeum vulgare 1035  
HORVU1Hr1G005980.21 PAC:38478008 Hordeum vulgare 998  
HORVU1Hr1G005980.23 PAC:38478012 Hordeum vulgare 985  
HORVU1Hr1G005980.16 PAC:38478010 Hordeum vulgare 998  
HORVU1Hr1G005980.15 PAC:38478011 Hordeum vulgare 998  
Brahy.D01G0707600.1.p PAC:38615751 Brachypodium hybridum 975  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9034168
            3118181
            11781113
            6088227