Protein Domain : IPR016592

Type:  Family Name:  Nibrin
Description:  Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and nibrin, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis [, , , , , ]. Mutations in the NBN gene coding for nibrin cause the Nijmegen Breakage Syndrome (NBS), a rare autosomal recessive disorder characterised by genomic instability and increased risk of haematopoietic malignancies [, ]. Short Name:  Nibrin_met
Paste the following link

0 Child Features

3 Contains

DB identifier Type Name
IPR000253 Domain Forkhead-associated (FHA) domain
IPR001357 Domain BRCT domain
IPR013908 Domain DNA repair Nbs1, C-terminal

1 Cross References

Identifier
PIRSF011869

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0000723 IPR016592
GO:0006281 IPR016592
GO:0006974 IPR016592
GO:0007093 IPR016592
GO:0005634 IPR016592
GO:0030870 IPR016592

6 Ontology Annotations

GO Term Gene Name
GO:0000723 IPR016592
GO:0006281 IPR016592
GO:0006974 IPR016592
GO:0007093 IPR016592
GO:0005634 IPR016592
GO:0030870 IPR016592

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9705271
            22373003
            25119968
            12422221
            10888888
            19759395
            15668383
            11448772