| Type: | Family | Name: | Mitochondrial carrier protein |
| Description: | A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [, , , ]. Such proteins include:ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. This family also includes peroxisomal proteins like PMP34 [].Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity []. The TM regions,and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins []. All members of the family appear to consistof a tripartite structure, each of the repeated segments being about 100 residues in length []. Each repeat contains two TM domains, the first being morehydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where - denotesany residue and Hy is a hydrophobic position []. | Short Name: | Mit_carrier |
