Protein Domain : IPR015947

Type:  Domain Name:  PUA-like domain
Description:  This entry represents domains with a PUA-like structure, consisting of a pseudo-barrel composed of mixed folded sheets of five strands. This structural motif is found in:PUA-containing proteins.The N-terminal of ATP sulphurylases, which contains extra structures, some similar to the PK beta-barrel domain [].Several bacterial hypothetical proteins, such as the N-terminal domain of YggJ [].The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found []. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [, ]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA []. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases []. Short Name:  PUA-like_domain
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6 Child Features

DB identifier Type Name
IPR025980 Domain ATP-sulfurylase PUA-like domain
IPR007374 Domain ASCH domain
IPR002478 Domain PUA domain
IPR002740 Domain EVE domain
IPR015240 Domain tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal
IPR015225 Domain tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal

0 Contains

2 Cross Referencess

Identifier
G3DSA:2.30.130.10
SSF88697

5 Found Ins

DB identifier Type Name
IPR005155 Family Ribosome biogenesis factor NIP7-like
IPR006700 Family Ribosomal RNA small subunit methyltransferase E
IPR022430 Family Conserved hypothetical protein CHP03684
IPR020792 Family Sulphate adenylyltransferase, prokaryotic-type
IPR009326 Family Protein of unknown function DUF984

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
78465 PAC:15421474 Selaginella moellendorffii 183  
79020 PAC:15421272 Selaginella moellendorffii 183  
51852 D8RRN1 PAC:15412110 Selaginella moellendorffii 585  
99851 D8RQZ4 PAC:15419646 Selaginella moellendorffii 417  
71422 D8RRY5 PAC:15423282 Selaginella moellendorffii 158  
141788 D8QWE3 PAC:15412071 Selaginella moellendorffii 879  
30423 D8QXF0 PAC:15414090 Selaginella moellendorffii 928  
405160 D8QWE9 PAC:15410905 Selaginella moellendorffii 432  
79965 D8QYE1 PAC:15405973 Selaginella moellendorffii 491  
80724 D8QWL8 PAC:15407491 Selaginella moellendorffii 258  
104841 D8RZ91 PAC:15415085 Selaginella moellendorffii 571  
417664 D8S364 PAC:15405320 Selaginella moellendorffii 177  
109372 D8S663 PAC:15403472 Selaginella moellendorffii 570  
418840 D8S6J6 PAC:15409804 Selaginella moellendorffii 105  
81986 D8QZK9 PAC:15412220 Selaginella moellendorffii 530  
444435 D8SAJ0 PAC:15416609 Selaginella moellendorffii 432  
439149 D8R2T4 PAC:15421677 Selaginella moellendorffii 788  
406755 D8R2U5 PAC:15418374 Selaginella moellendorffii 508  
407168 D8R446 PAC:15416698 Selaginella moellendorffii 178  
133737 D8T7J6 PAC:15410648 Selaginella moellendorffii 551  
403061 D8QNX6 PAC:15404132 Selaginella moellendorffii 186  
126335 D8SW28 PAC:15409095 Selaginella moellendorffii 266  
426107 D8SVC0 PAC:15405656 Selaginella moellendorffii 326  
77083 D8QTI8 PAC:15415718 Selaginella moellendorffii 610  
67646 D8R9N8 PAC:15413003 Selaginella moellendorffii 217  
269807 D8T779 PAC:15420067 Selaginella moellendorffii 541  
evm.TU.contig_29644.1 PAC:16429717 Carica papaya 677  
evm.TU.contig_35178.1 PAC:16430602 Carica papaya 33  
evm.TU.contig_35939.1 PAC:16430746 Carica papaya 840  
evm.TU.contig_36397.1 PAC:16430828 Carica papaya 152  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16943774
            10093218
            17803682
            16793063
            16407303
            14517985
            11157739