Protein Domain : IPR015240

Type:  Domain Name:  tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal
Description:  Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine (Psi) in a variety of RNA molecules, and may function as RNA chaperones. Pseudouridine is the most abundant modified nucleotide found in all cellular RNAs. There are four distinct families of pseudouridine synthases that share no global sequence similarity, but which do share the same fold of their catalytic domain(s) and uracil-binding site and are descended from a common molecular ancestor. The catalytic domain consists of two subdomains, each of which has an alpha+beta structure that has some similarity to the ferredoxin-like fold (note: some pseudouridine synthases contain additional domains). The active site is the most conserved structural region of the superfamily and is located between the two homologous domains. These families are []:Pseudouridine synthase I, TruA.Pseudouridine synthase II, TruB, which contains and additional C-terminal PUA domain.Pseudouridine synthase RsuA (ribosomal small subunit) and RluC/RluD (ribosomal large subunits), both of which contain an additional N-terminal alpha-L RNA-binding motif.Pseudouridine synthase TruD, which has a natural circular permutation in the catalytic domain, as well as an insertion of a family-specific alpha+beta subdomain.TruB is responsible for the pseudouridine residue present in the T loops of virtually all tRNAs. TruB recognises the preformed 3-D structure of the T loop primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA []. The C-terminal domain adopts a secondary structure consisting of a four-stranded beta sheet and one alpha helix, similar to that found in PUA domains. It is predominantly involved in RNA-binding, being mostly found in tRNA pseudouridine synthase B (TruB) []. Short Name:  tRNA_sdUridine_synth_fam1_C
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0 Child Features

0 Contains

1 Cross References

Identifier
PF09157

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003723 IPR015240
GO:0009982 IPR015240
GO:0001522 IPR015240
GO:0009451 IPR015240

4 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR015240
GO:0009982 IPR015240
GO:0001522 IPR015240
GO:0009451 IPR015240

1 Parent Features

DB identifier Type Name
IPR015947 Domain PUA-like domain

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0094.1.p PAC:28856407 Arabidopsis halleri 310  
Brdisv1pangenome1008417m.p PAC:33598782 Brachypodium distachyon Pangenome 288  
Brdisv1pangenome1009531m.p PAC:33657881 Brachypodium distachyon Pangenome 369  
Brdisv1pangenome1010637m.p PAC:33658790 Brachypodium distachyon Pangenome 306  
Brdisv1BdTR11A1048684m.p PAC:35688162 Brachypodium distachyon BdTR11a 634  
Brdisv1BdTR11A1047622m.p PAC:35687772 Brachypodium distachyon BdTR11a 419  
Brdisv1BdTR11A1044117m.p PAC:35690595 Brachypodium distachyon BdTR11a 288  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10529181
            11779468
            15028724