Protein Domain : IPR000209

Type:  Domain Name:  Peptidase S8/S53 domain
Description:  This entry represents a domain found in serine peptidases belonging to the MEROPS peptidase families S8 (subfamilies S8A (subtilisin) and S8B (kexin)) and S53 (sedolisin), both of which are members of clan SB.The subtilisin family is the second largest serine protease family characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence []. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses []. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase [, ]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity [, ]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein []. Based on sequence homology, a subdivision into six families has been proposed []. The proprotein-processing endopeptidases kexin, furin and related enzymes form a distinct subfamily known as the kexin subfamily (S8B). These preferentiallycleave C-terminally to paired basic amino acids. Members of this subfamily can be identified by subtly different motifs around the active site [, ].Members of the kexin family, along with endopeptidases R, T and K from the yeast Tritirachium and cuticle-degrading peptidase from Metarhizium, requirethiol activation. This can be attributed to the presence of Cys-173 near to the active histidine [].Only 1 viral member of the subtilisin family is known, a 56kDa protease from herpes virus 1, which infects the channel catfish []. Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold resembles that of subtilisin; however, they are considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The definingfeatures of these enzymes are a unique catalytic triad, Ser-Glu-Asp, as well as the presence of an aspartic acid residue in the oxyanion hole. High-resolution crystal structures have now been solved for sedolisin from Pseudomonas sp. 101, as well as for kumamolisin from a thermophilic bacterium, Bacillus sp. MN-32. Mutations in the human gene leads to a fatal neurodegenerative disease []. Short Name:  Peptidase_S8/S53_dom
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1 Child Features

DB identifier Type Name
IPR030400 Domain Sedolisin domain

2 Contains

DB identifier Type Name
IPR003137 Domain PA domain
IPR022398 Active_site Peptidase S8, subtilisin, His-active site

3 Cross Referencess

Identifier
PF00082
G3DSA:3.40.50.200
SSF52743

21 Found Ins

DB identifier Type Name
IPR015500 Family Peptidase S8, subtilisin-related
IPR017292 Family Peptidase S8A, Vpr
IPR016625 Family Uncharacterised conserved protein UCP014872, subtilisin-related
IPR016916 Family Uncharacterised conserved protein UCP029389, subtilisin-related
IPR012103 Family Peptidase S8A, bacillopeptidase F
IPR017310 Family Peptidase S8A, subtilisin-related, clostridia
IPR017312 Family Peptidase S8A, subtilisin-related, Alteromonadales
IPR017314 Family Peptidase S8A, subtilisin-like peptidase 1, plasmodium
IPR017315 Family Peptidase S8A, subtilisin-related, proteobacteria-2
IPR017316 Family Peptidase S8A, subtilisin-related, cyanobacteria-2
IPR017317 Family Peptidase S8A, subtilisin-related, bacteroidetes-2
IPR017318 Family Peptidase S8A, subtilisin-related, campylobacter
IPR017319 Family Subtilisin-like serine protease TK1689-type
IPR008357 Family Lantibiotic leader peptide-processing serine protease
IPR017001 Family Peptidase S53, physarolisin II, archaeal-type
IPR017294 Family Peptidase S8A, subtilisin-related protease, kinetoplastidia
IPR017295 Family Peptidase S8A, subtilisin-related, cyanobacteria-1
IPR017296 Family Peptidase S8A, SAM-P45
IPR017297 Family Peptidase S8A, DPH-A
IPR017308 Family Peptidase S8A, subtilisin-related, bacteroidetes
IPR017309 Family Peptidase S8A, subtilisin-related, proteobacteria

2 GO Annotations

GO Term Gene Name
GO:0004252 IPR000209
GO:0006508 IPR000209

2 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR000209
GO:0006508 IPR000209

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410831 D8RG03 PAC:15408665 Selaginella moellendorffii 1366  
411167 D8RGS5 PAC:15406331 Selaginella moellendorffii 742  
172478 D8RLV7 PAC:15411963 Selaginella moellendorffii 742  
412516 D8RLQ7 PAC:15412242 Selaginella moellendorffii 757  
96495 D8RLP8 PAC:15407798 Selaginella moellendorffii 681  
404186 D8QUJ2 PAC:15407880 Selaginella moellendorffii 284  
61337 D8QW76 PAC:15415506 Selaginella moellendorffii 718  
267609 D8RQM6 PAC:15412711 Selaginella moellendorffii 698  
414627 D8RTE5 PAC:15418903 Selaginella moellendorffii 533  
414628 D8RTE6 PAC:15418906 Selaginella moellendorffii 636  
414626 D8RTE4 PAC:15418900 Selaginella moellendorffii 138  
414624 D8RTE2 PAC:15418898 Selaginella moellendorffii 258  
102404 D8RV88 PAC:15405986 Selaginella moellendorffii 784  
102824 D8RV85 PAC:15409140 Selaginella moellendorffii 537  
150329 D8RVJ4 PAC:15413207 Selaginella moellendorffii 692  
18118 D8RV18 PAC:15420648 Selaginella moellendorffii 105  
415166 D8RV83 PAC:15418049 Selaginella moellendorffii 860  
415194 D8RVB8 PAC:15418119 Selaginella moellendorffii 761  
442725 D8RVK3 PAC:15413117 Selaginella moellendorffii 1213  
416154 D8RY94 PAC:15420927 Selaginella moellendorffii 576  
405382 D8QX60 PAC:15412476 Selaginella moellendorffii 616  
417354 D8S1Y6 PAC:15403003 Selaginella moellendorffii 475  
107351 D8S3M5 PAC:15419995 Selaginella moellendorffii 721  
107394 D8S3M6 PAC:15420107 Selaginella moellendorffii 727  
417799 D8S3N3 PAC:15406203 Selaginella moellendorffii 830  
417798 D8S3N2 PAC:15406200 Selaginella moellendorffii 522  
417795 D8S3M9 PAC:15406195 Selaginella moellendorffii 603  
417793 D8S3M7 PAC:15406192 Selaginella moellendorffii 388  
417801 D8S3N5 PAC:15406736 Selaginella moellendorffii 696  
110049 D8S6R0 PAC:15404306 Selaginella moellendorffii 710  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8439290
            7845208
            9070434
            12673349