Protein Domain : IPR022398

Type:  Active_site Name:  Peptidase S8, subtilisin, His-active site
Description:  Subtilases [] are an extensive family of serine proteases belonging to the MEROPS peptidase family S8 (subtilisin, clan SB). Members of this family have a catalytic triad in the order Asp, His and Ser in the sequence, which is a different order to that of families S1, S9 and S10. The catalytic activity is provided by a charge relay system similar to that of the trypsin family of serine proteases but which evolved by independent convergent evolution. The sequence around the residues involved in the catalytic triad (Asp, Ser and His) are completely different from that of the analogous residues in the trypsin serine proteases and can be used as signatures specific to that category of proteases. If a protein includes at least two of the three active site signatures, the probability of it being a serine protease from the subtilase family is 100%.This entry represents the conserved sequence around the His active site. Short Name:  Peptidase_S8_His-AS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00137

17 Found Ins

DB identifier Type Name
IPR015500 Family Peptidase S8, subtilisin-related
IPR000209 Domain Peptidase S8/S53 domain
IPR017292 Family Peptidase S8A, Vpr
IPR016916 Family Uncharacterised conserved protein UCP029389, subtilisin-related
IPR012103 Family Peptidase S8A, bacillopeptidase F
IPR017310 Family Peptidase S8A, subtilisin-related, clostridia
IPR017312 Family Peptidase S8A, subtilisin-related, Alteromonadales
IPR017314 Family Peptidase S8A, subtilisin-like peptidase 1, plasmodium
IPR017315 Family Peptidase S8A, subtilisin-related, proteobacteria-2
IPR017316 Family Peptidase S8A, subtilisin-related, cyanobacteria-2
IPR017318 Family Peptidase S8A, subtilisin-related, campylobacter
IPR017319 Family Subtilisin-like serine protease TK1689-type
IPR008357 Family Lantibiotic leader peptide-processing serine protease
IPR017296 Family Peptidase S8A, SAM-P45
IPR017297 Family Peptidase S8A, DPH-A
IPR017308 Family Peptidase S8A, subtilisin-related, bacteroidetes
IPR017309 Family Peptidase S8A, subtilisin-related, proteobacteria

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1798697