Protein Domain : IPR015500

Type:  Family Name:  Peptidase S8, subtilisin-related
Description:  This entry contains serine endopeptidases belonging to the MEROPS peptidase family S8 (subtilisin family , clan SB). Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes []. The subtilisin-serine protease (SRSP) family hormone and pro-protein convertases (furin, PC1/3, PC2, PC4, PACE4, PC5/6, and PC7/7/LPC) act within the secretory pathway to cleave polypeptide precursors at specific basic sites, generating their biologically active forms. Serum proteins, pro-hormones, receptors, zymogens, viral surface glycoproteins, bacterial toxins, amongst others, are activated by this route []. The SRSPs share the same domain structure, including a signal peptide, the pro-peptide, the catalytic domain, the P/middle or homo B domain, and the C terminus. Short Name:  Peptidase_S8_subtilisin-rel
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20 Child Features

DB identifier Type Name
IPR017292 Family Peptidase S8A, Vpr
IPR016916 Family Uncharacterised conserved protein UCP029389, subtilisin-related
IPR012103 Family Peptidase S8A, bacillopeptidase F
IPR017310 Family Peptidase S8A, subtilisin-related, clostridia
IPR017312 Family Peptidase S8A, subtilisin-related, Alteromonadales
IPR017314 Family Peptidase S8A, subtilisin-like peptidase 1, plasmodium
IPR017315 Family Peptidase S8A, subtilisin-related, proteobacteria-2
IPR017316 Family Peptidase S8A, subtilisin-related, cyanobacteria-2
IPR017317 Family Peptidase S8A, subtilisin-related, bacteroidetes-2
IPR017318 Family Peptidase S8A, subtilisin-related, campylobacter
IPR017319 Family Subtilisin-like serine protease TK1689-type
IPR008357 Family Lantibiotic leader peptide-processing serine protease
IPR017294 Family Peptidase S8A, subtilisin-related protease, kinetoplastidia
IPR017295 Family Peptidase S8A, subtilisin-related, cyanobacteria-1
IPR017296 Family Peptidase S8A, SAM-P45
IPR017297 Family Peptidase S8A, DPH-A
IPR017308 Family Peptidase S8A, subtilisin-related, bacteroidetes
IPR017309 Family Peptidase S8A, subtilisin-related, proteobacteria
IPR023830 Family Peptidase S8A, PatG
IPR023834 Family Type VII secretion system peptidase S8A, mycosin-1

4 Contains

DB identifier Type Name
IPR010259 Domain Peptidase S8 propeptide/proteinase inhibitor I9
IPR003137 Domain PA domain
IPR000209 Domain Peptidase S8/S53 domain
IPR022398 Active_site Peptidase S8, subtilisin, His-active site

2 Cross Referencess

Identifier
PTHR10795
PR00723

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410831 D8RG03 PAC:15408665 Selaginella moellendorffii 1366  
411167 D8RGS5 PAC:15406331 Selaginella moellendorffii 742  
411932 D8RJH5 PAC:15412450 Selaginella moellendorffii 158  
172478 D8RLV7 PAC:15411963 Selaginella moellendorffii 742  
412516 D8RLQ7 PAC:15412242 Selaginella moellendorffii 757  
96495 D8RLP8 PAC:15407798 Selaginella moellendorffii 681  
404186 D8QUJ2 PAC:15407880 Selaginella moellendorffii 284  
61337 D8QW76 PAC:15415506 Selaginella moellendorffii 718  
267609 D8RQM6 PAC:15412711 Selaginella moellendorffii 698  
414627 D8RTE5 PAC:15418903 Selaginella moellendorffii 533  
414628 D8RTE6 PAC:15418906 Selaginella moellendorffii 636  
414626 D8RTE4 PAC:15418900 Selaginella moellendorffii 138  
414624 D8RTE2 PAC:15418898 Selaginella moellendorffii 258  
102404 D8RV88 PAC:15405986 Selaginella moellendorffii 784  
102841 D8RV16 PAC:15409188 Selaginella moellendorffii 78  
102824 D8RV85 PAC:15409140 Selaginella moellendorffii 537  
150329 D8RVJ4 PAC:15413207 Selaginella moellendorffii 692  
18118 D8RV18 PAC:15420648 Selaginella moellendorffii 105  
415166 D8RV83 PAC:15418049 Selaginella moellendorffii 860  
415194 D8RVB8 PAC:15418119 Selaginella moellendorffii 761  
442725 D8RVK3 PAC:15413117 Selaginella moellendorffii 1213  
416154 D8RY94 PAC:15420927 Selaginella moellendorffii 576  
405382 D8QX60 PAC:15412476 Selaginella moellendorffii 616  
417354 D8S1Y6 PAC:15403003 Selaginella moellendorffii 475  
107351 D8S3M5 PAC:15419995 Selaginella moellendorffii 721  
107394 D8S3M6 PAC:15420107 Selaginella moellendorffii 727  
417799 D8S3N3 PAC:15406203 Selaginella moellendorffii 830  
417798 D8S3N2 PAC:15406200 Selaginella moellendorffii 522  
417795 D8S3M9 PAC:15406195 Selaginella moellendorffii 603  
417793 D8S3M7 PAC:15406192 Selaginella moellendorffii 388  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10656993
            9572109