| Type: | Family | Name: | Glycoside hydrolase, family 27 |
| Description: | O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 27 comprises enzymes with several known activities; alpha-galactosidase (); alpha-N-acetylgalactosaminidase (); isomalto-dextranase ().Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose []. In man, deficiency in the enzyme results inFabry's disease (X-linked sphingolipidosis). Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamineresidues in N-acetyl-alpha-D-galactosaminides []. Two conserved Asp residues may be involved in the catalytic mechanism in these enzymes. Deficiency in this enzyme results in Schindler and Kanzaki diseases. | Short Name: | Glyco_hydro_27 |
