| Type: | Family | Name: | Glycoside hydrolase, melibiase |
| Description: | O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Families 27 () and 36 () encompasses alpha-galactosidases and alpha-N-acetylgalactosaminidases in which two conserved Asp residues may be involved in the catalytic mechanism. Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose []. In man, deficiency in the enzyme results in Fabry's disease (X-linked sphingolipidosis). Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides []. Deficiency in this enzyme results in Schindler and Kanzaki diseases.This group identifies specifically melibiase. | Short Name: | Glyco_hydro_melibiase |
