Protein Domain : IPR016181

Type:  Domain Name:  Acyl-CoA N-acyltransferase
Description:  This entry represents a structural domain found in several acyl-CoA acyltransferase enzymes. This domain has a 3-layer alpha/beta/alpha structure that contains mixed beta-sheets, and can be found in the following proteins:N-acetyl transferase (NAT) family members, including aminoglycoside N-acetyltransferases [], the histone acetyltransferase domain of P300/CBP associating factor PCAF [], the catalytic domain of GCN5 histone acetyltransferase [], and diamine acetyltransferase 1 [].Autoinducer synthetases, such as protein LasI [] and acyl-homoserinelactone synthase EsaI [].Leucyl/phenylalanyl-tRNA-protein transferase (LFTR), a close relative of the non-ribosomal peptidyltransferases; there is a deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events [].Ornithine decarboxylase antizyme, which may have evolved a different function for this domain, although the putative active site maps to the same location in the common fold.Arginine N-succinyltransferase, alpha chain, AstA, which contains an extra C-terminal domain that is similar to the double psi beta-barrel fold domain (missing one strand and untangled psi-loops).Several proteins carry a duplication of this domain, which consists of two NAT-like domains swapped with the C-terminal strands, including:N-myristoyl transferase (NMT) [].FemXAB nonribosomal peptidyltransferases, including methicillin-resistance protein FemA (transfer glycyl residue from tRNA-Gly) [] and peptidyltransferase FemX [].Hypothetical protein cg14615-pa from Drosophila melanogaster(Fruit fly). Short Name:  Acyl_CoA_acyltransferase
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4 Child Features

DB identifier Type Name
IPR002717 Domain Histone acetyltransferase domain, MYST-type
IPR000182 Domain GNAT domain
IPR031165 Domain Yjdj-type Gcn5-related N-acetyltransferase
IPR001690 Domain Autoinducer synthase

10 Contains

DB identifier Type Name
IPR022676 Domain Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
IPR022677 Domain Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
IPR019467 Domain Histone acetyl transferase HAT1 N-terminal
IPR013653 Domain FR47-like
IPR019432 Domain Siderophore biosynthesis protein, conserved domain
IPR009658 Domain Domain of unknown function DUF1248
IPR018311 Conserved_site Autoinducer synthesis, conserved site
IPR013652 Domain Glycine N-acyltransferase, C-terminal
IPR022678 Conserved_site Myristoyl-CoA:protein N-myristoyltransferase, conserved site
IPR015938 Domain Glycine N-acyltransferase, N-terminal

2 Cross Referencess

Identifier
G3DSA:3.40.630.30
SSF55729

11 Found Ins

DB identifier Type Name
IPR000903 Family Myristoyl-CoA:protein N-myristoyltransferase
IPR007434 Family Peptidogalycan biosysnthesis/recognition
IPR017380 Family Histone acetyltransferase type B, catalytic subunit
IPR001690 Domain Autoinducer synthase
IPR003447 Family FemABX peptidyl transferase
IPR007041 Family Arginine N-succinyltransferase AstA/AruG
IPR017650 Family Arginine N-succinyltransferase
IPR011242 Family Acetylglutamate kinase argB
IPR017469 Family PEP-CTERM system-associated, FemAB-related
IPR010313 Family Glycine N-acyltransferase
IPR010037 Domain FkbH domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231364 D8RF03 PAC:15416089 Selaginella moellendorffii 196  
93596 D8RHS7 PAC:15422092 Selaginella moellendorffii 196  
94349 D8RIN2 PAC:15423391 Selaginella moellendorffii 115  
449074 D8TCE6 PAC:15405897 Selaginella moellendorffii 187  
412706 D8RL82 PAC:15413821 Selaginella moellendorffii 385  
412723 D8RL98 PAC:15413891 Selaginella moellendorffii 360  
58956 D8RLU2 PAC:15411096 Selaginella moellendorffii 147  
96899 D8RL74 PAC:15411019 Selaginella moellendorffii 557  
432070 D8TEW4 PAC:15422822 Selaginella moellendorffii 500  
97255 D8RMA0 PAC:15409200 Selaginella moellendorffii 220  
78184 D8QWA1 PAC:15419349 Selaginella moellendorffii 198  
413610 D8RQU5 PAC:15415958 Selaginella moellendorffii 259  
99282 D8RQS7 PAC:15415149 Selaginella moellendorffii 99  
415324 D8RVR8 PAC:15419481 Selaginella moellendorffii 192  
175390 D8RY95 PAC:15419979 Selaginella moellendorffii 590  
104443 D8RXU8 PAC:15411990 Selaginella moellendorffii 418  
80470 D8QWL5 PAC:15405337 Selaginella moellendorffii 461  
417267 D8S2N7 PAC:15402309 Selaginella moellendorffii 349  
417273 D8S2P2 PAC:15402324 Selaginella moellendorffii 312  
443492 D8S2N1 PAC:15413964 Selaginella moellendorffii 557  
18298 D8S6Z4 PAC:15421486 Selaginella moellendorffii 115  
438921 D8R0G8 PAC:15402536 Selaginella moellendorffii 215  
6403 D8QZY3 PAC:15421440 Selaginella moellendorffii 139  
419679 D8S9P6 PAC:15411311 Selaginella moellendorffii 1411  
444359 D8S9B0 PAC:15415954 Selaginella moellendorffii 346  
7816 D8SBI4 PAC:15405193 Selaginella moellendorffii 112  
23264 D8R0U4 PAC:15414209 Selaginella moellendorffii 363  
271611 D8SIQ9 PAC:15402315 Selaginella moellendorffii 249  
234338 D8SK44 PAC:15402366 Selaginella moellendorffii 396  
84658 D8R327 PAC:15418631 Selaginella moellendorffii 408  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12592013
            14962386
            10430873
            12176388
            10393169
            11371195
            11931774
            15306017
            16455797
            17242373