Protein Domain : IPR000182

Type:  Domain Name:  GNAT domain
Description:  The N-acetyltransferases (NAT) (EC 2.3.1.-) are enzymes that use acetyl coenzyme A (CoA) to transfer an acetyl group to a substrate, a reactionimplicated in various functions from bacterial antibiotic resistance to mammalian circadian rhythm and chromatin remodeling. The Gcn5-relatedN-acetyltransferases (GNAT) catalyze the transfer of the acetyl from the CoA donor to a primary amine of the acceptor. The GNAT proteins share a domaincomposed of four conserved sequence motifs A-D [, ]. This GNAT domain is named after yeast GCN5 (from General Control Nonrepressed) and related histone acetyltransferases (HATs) like Hat1 and PCAF. HATs acetylate lysine residues of amino terminal histone tails, resulting in transcription activation. Another category of GNAT, the aminoglycoside N-acetyltransferases, confer antibiotic resistance by catalyzing the acetylation of amino groups in aminoglycoside antibiotics []. GNAT proteins can also have anabolic and catabolic functions in both prokaryotes and eukaryotes [, , , , ].The acetyltransferase/GNAT domain forms a structurally conserved fold of 6 to 7 beta strands (B) and 4 helices (H) in the topology B1-H1-H2-B2-B3-B4-H3-B5-H4-B6, followed by a C-terminal strand which may be from the same monomer or contributed by another [, ]. Motifs D (B2-B3), A (B4-H3) and B (B5-H4) are collectively called the HAT core[, , ], while the N-terminal motif C (B1-H1) is less conserved.Some proteins known to contain a GNAT domain:Yeast GCN5 and Hat1, which are histone acetyltransferases (EC 2.3.1.48).Human PCAF, a histone acetyltransferase.Mammalian serotonin N-acetyltransferase (SNAT) or arylalkylamine NAT (AANAT), which acetylates serotonin into a circadian neurohormone that mayparticipate in light-dark rhythms, and human mood and behavior.Mammalian glucosamine 6-phosphate N-acetyltransferase (GNA1) (EC 2.3.1.4).Escherichia coli rimI and rimJ, which acetylate the N-terminal alanine of ribosomal proteins S18 and S5, respectively (EC 2.3.1.128).Mycobacterium tuberculosis aminoglycoside 2'-N-acetyltransferase (aac), which acetylates the 2' hydroxyl or amino group of a broad spectrum ofaminoglycoside antibiotics.Bacillus subtilis bltD and paiA, which acetylate spermine and spermidine.This entry represents the entire GNAT domain. Short Name:  GNAT_dom
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0 Child Features

0 Contains

6 Cross Referencess

Identifier
PF00583
PF13302
PF13508
PF13673
PF13718
PS51186

14 Found Ins

DB identifier Type Name
IPR010167 Family Amino-acid N-acetyltransferase (ArgA)
IPR005910 Family Histone acetyltransferase ELP3
IPR016376 Family Histone acetylase PCAF
IPR012752 Family TDP-D-fucosamine acetyltransferase WecD
IPR016794 Family Uncharacterised conserved protein UCP21603, acetyltransferase-like
IPR005216 Family Citrate lyase ligase
IPR016890 Family Uncharacterised conserved protein UCP028520
IPR008125 Family Streptothricin acetyltransferase
IPR011244 Family Bifunctional argininosuccinate lyase/acetyltransferase
IPR012772 Family L-2,4-diaminobutyric acid acetyltransferase
IPR017255 Family Acetyltransferase, GNAT, predicted
IPR017274 Family Putative N-acetyltransferase YlbP
IPR017534 Family GNAT-acetyltransferase
IPR017813 Family Mycothiol acetyltransferase

1 GO Annotation

GO Term Gene Name
GO:0008080 IPR000182

1 Ontology Annotations

GO Term Gene Name
GO:0008080 IPR000182

1 Parent Features

DB identifier Type Name
IPR016181 Domain Acyl-CoA N-acyltransferase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231364 D8RF03 PAC:15416089 Selaginella moellendorffii 196  
93596 D8RHS7 PAC:15422092 Selaginella moellendorffii 196  
94349 D8RIN2 PAC:15423391 Selaginella moellendorffii 115  
449074 D8TCE6 PAC:15405897 Selaginella moellendorffii 187  
412706 D8RL82 PAC:15413821 Selaginella moellendorffii 385  
412723 D8RL98 PAC:15413891 Selaginella moellendorffii 360  
58956 D8RLU2 PAC:15411096 Selaginella moellendorffii 147  
96899 D8RL74 PAC:15411019 Selaginella moellendorffii 557  
97255 D8RMA0 PAC:15409200 Selaginella moellendorffii 220  
413610 D8RQU5 PAC:15415958 Selaginella moellendorffii 259  
175390 D8RY95 PAC:15419979 Selaginella moellendorffii 590  
104443 D8RXU8 PAC:15411990 Selaginella moellendorffii 418  
80470 D8QWL5 PAC:15405337 Selaginella moellendorffii 461  
417267 D8S2N7 PAC:15402309 Selaginella moellendorffii 349  
417273 D8S2P2 PAC:15402324 Selaginella moellendorffii 312  
443492 D8S2N1 PAC:15413964 Selaginella moellendorffii 557  
438921 D8R0G8 PAC:15402536 Selaginella moellendorffii 215  
6403 D8QZY3 PAC:15421440 Selaginella moellendorffii 139  
444359 D8S9B0 PAC:15415954 Selaginella moellendorffii 346  
23264 D8R0U4 PAC:15414209 Selaginella moellendorffii 363  
271611 D8SIQ9 PAC:15402315 Selaginella moellendorffii 249  
122523 D8SQ85 PAC:15421158 Selaginella moellendorffii 222  
139448 D8QQ84 PAC:15403451 Selaginella moellendorffii 519  
86274 D8R5W4 PAC:15421341 Selaginella moellendorffii 236  
130536 D8T2M0 PAC:15422582 Selaginella moellendorffii 193  
125041 D8SUG6 PAC:15403782 Selaginella moellendorffii 502  
126619 D8SWC0 PAC:15411409 Selaginella moellendorffii 220  
89918 D8RBD8 PAC:15413181 Selaginella moellendorffii 558  
231183 D8RBT0 PAC:15414677 Selaginella moellendorffii 377  
140315 D8QTH4 PAC:15405853 Selaginella moellendorffii 1015  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9175471
            12527305
            12592013
            10940244
            15581578