| Type: | Domain | Name: | FkbH domain |
| Description: | This entry describes a domain of unknown function. One of proteins with this domain is a modular polyketide synthase, which is 4800 amino acids in length from Streptomyces avermitilis, where the domain is the C-terminal segment. By contrast, the FkbH protein from Streptomyces hygroscopicus() apparently contains only this domain. The remaining members of the family all contain an additional N-terminal domain of between 200 and 275 amino acids, which show less than 20% identity to one another. It seems likely then that these proteins are involved in disparate functions, probably the biosynthesis of different natural products. For instance, the FkbH gene is found in a gene cluster believed to be responsible for the biosynthesis of unusual 'PKS extender units' in the ascomycin pathway []. This domain is composed of two parts, the first of which is a member of subfamily IIIC of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. All of the characterised enzymes within subfamily III are phosphatases, and all of the active site residues characteristic of HAD-superfamily phosphatases [] are present in this domain. The C-terminal portion of this domain is unique to this family (by BLAST). | Short Name: | FkbH_domain |
