Protein Domain : IPR011527

Type:  Domain Name:  ABC transporter type 1, transmembrane domain
Description:  ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules. The major function of ABC import systems is to provide essential nutrients to bacteria. They are found only in prokaryotes and their four constitutive domains are usually encoded by independent polypeptides (two ABC proteins and two TMD proteins). Prokaryotic importers require additional extracytoplasmic binding proteins (one or more per systems) for function. In contrast, export systems are involved in the extrusion of noxious substances, the export of extracellular toxins and the targeting of membrane components. They are found in all living organisms and in general the TMD is fused to the ABC module in a variety of combinations. Some eukaryotic exporters encode the four domains on the same polypeptide chain [].The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions []. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [, ]. More than 50 subfamilies have been described based on a phylogenetic and functional classification [, , ]; (for further information see http://www.tcdb.org/tcdb/index.php?tc=3.A.1).ABC transporters minimally contain two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). In certain bacterial transporters, these regions are found on different polypeptides. The function of the integral inner-membrane protein is to translocate the substrate across the membrane, as well as in substrate recognition [, ].This entry represents the transmembrane domain in cases where the TMD and ABC region are found in the same protein. Short Name:  ABC1_TM_dom
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF00664
PF06472
PF13748
PS50929
SSF90123

7 Found Ins

DB identifier Type Name
IPR009248 Family SbmA/BacA-like
IPR000388 Family Sulphonylurea receptor
IPR000844 Family ATP-binding cassette subfamily C member 8
IPR001475 Family ATP-binding cassette subfamily C member 9
IPR022514 Family NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein
IPR022515 Family NHPM bacteriocin system ABC transporter, ATP-binding protein
IPR013305 Family ABC transporter Tap-like

5 GO Annotations

GO Term Gene Name
GO:0005524 IPR011527
GO:0042626 IPR011527
GO:0006810 IPR011527
GO:0055085 IPR011527
GO:0016021 IPR011527

5 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR011527
GO:0042626 IPR011527
GO:0006810 IPR011527
GO:0055085 IPR011527
GO:0016021 IPR011527

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410515 D8REZ9 PAC:15406347 Selaginella moellendorffii 1222  
92485 D8RF00 PAC:15418498 Selaginella moellendorffii 1239  
171469 D8RH21 PAC:15408949 Selaginella moellendorffii 1276  
93699 D8RHJ5 PAC:15422875 Selaginella moellendorffii 1404  
231714 D8RIL0 PAC:15419034 Selaginella moellendorffii 1105  
147933 D8RKQ9 PAC:15408634 Selaginella moellendorffii 1467  
61383 D8RLZ0 PAC:15415598 Selaginella moellendorffii 596  
441803 D8RMN8 PAC:15410892 Selaginella moellendorffii 639  
165716 D8QW54 PAC:15415724 Selaginella moellendorffii 1367  
230134 D8QVC0 PAC:15411565 Selaginella moellendorffii 1329  
438238 D8QV80 PAC:15419600 Selaginella moellendorffii 589  
78362 D8QU09 PAC:15420833 Selaginella moellendorffii 479  
148837 D8RQL9 PAC:15410912 Selaginella moellendorffii 1214  
99030 D8RPR3 PAC:15413525 Selaginella moellendorffii 1262  
99885 D8RR38 PAC:15419725 Selaginella moellendorffii 1218  
100977 D8RT17 PAC:15404084 Selaginella moellendorffii 617  
94 D8QXT0 PAC:15402625 Selaginella moellendorffii 1032  
105244 D8RZ51 PAC:15413445 Selaginella moellendorffii 608  
106184 D8S1Q5 PAC:15415682 Selaginella moellendorffii 1270  
107555 D8S3J3 PAC:15421410 Selaginella moellendorffii 777  
176522 D8S3C1 PAC:15401958 Selaginella moellendorffii 1246  
417560 D8S2V2 PAC:15404511 Selaginella moellendorffii 1494  
417772 D8S3K3 PAC:15406130 Selaginella moellendorffii 777  
417771 D8S3K2 PAC:15406129 Selaginella moellendorffii 1226  
405957 D8R074 PAC:15416980 Selaginella moellendorffii 588  
81581 D8R085 PAC:15409136 Selaginella moellendorffii 1599  
233433 D8S905 PAC:15422531 Selaginella moellendorffii 1216  
419451 D8S902 PAC:15409676 Selaginella moellendorffii 939  
230611 D8R130 PAC:15415378 Selaginella moellendorffii 1161  
230688 D8R3R8 PAC:15415534 Selaginella moellendorffii 1243  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9873074
            11421269
            11421270
            10529352