Protein Domain : IPR000844

Type:  Family Name:  ATP-binding cassette subfamily C member 8
Description:  ATP-binding cassette subfamily C member 8 (ABCC8, also known as the sulphonylurea receptor SUR1) is a member of the ABC transporter family. ABCC8 is comprised of three transmembrane helical bundles, TMD0, TMD1 and TMD2. It also contains two cytosolic nucleotide binding domains (NBDs) located between TMD1 and TMD2 and in the cytoplasmic C-terminal domain, respectively []. It is a regulator of the potassium ATP channel. Its NBD domains control channel activity through their interaction with cytosolic nucleotides []. Together with ABCC9 (SUR2), ABCC8 regulates the Kir6.2 potassium channel []. It also controls insulin secretion after feeding [].ABCC8 and 9 are the targets of sulphonylurea oral hypoglycaemic agents that are used widely for the treatment of non-insulin dependent diabetes mellitus and ABCC8 genetic variants have been linked to risk of the disease [, ]. Short Name:  ABCC8
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0 Child Features

3 Contains

DB identifier Type Name
IPR003439 Domain ABC transporter-like
IPR011527 Domain ABC transporter type 1, transmembrane domain
IPR017871 Conserved_site ABC transporter, conserved site

2 Cross Referencess

Identifier
PTHR24223:SF187
PR01093

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005524 IPR000844
GO:0008281 IPR000844
GO:0006813 IPR000844
GO:0016020 IPR000844

4 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR000844
GO:0008281 IPR000844
GO:0006813 IPR000844
GO:0016020 IPR000844

1 Parent Features

DB identifier Type Name
IPR000388 Family Sulphonylurea receptor

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10204114
            25143473
            24768178
            16416420
            18767144
            25236767