Protein Domain : IPR013305

Type:  Family Name:  ABC transporter Tap-like
Description:  The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].This entry includes Tap1/2 (transporter associated with antigen processing 1/2) and its homologue, Mdl2, from budding yeasts. They are a group of eukaryotic proteins belonging to the ABC transporter family. Tap proteins play a crucial role in the processing and presentation of the MHC class I-restricted antigens. Mdl2 is a mitochondrial inner membrane half-type ABC transporter that is required for respiratory growth at high temperature [, ]. Short Name:  ABC_Tap-like
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2 Child Features

DB identifier Type Name
IPR005293 Family Antigen peptide transporter 2
IPR013306 Family Antigen peptide transporter 1

3 Contains

DB identifier Type Name
IPR003439 Domain ABC transporter-like
IPR011527 Domain ABC transporter type 1, transmembrane domain
IPR017871 Conserved_site ABC transporter, conserved site

1 Cross References

Identifier
TIGR00958

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005524 IPR013305
GO:0015197 IPR013305
GO:0015833 IPR013305
GO:0016020 IPR013305

4 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR013305
GO:0015197 IPR013305
GO:0015833 IPR013305
GO:0016020 IPR013305

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11441126
            7912468
            11251115