Protein Domain : IPR010255

Type:  Family Name:  Haem peroxidase
Description:  Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions.Most haem peroxidases follow the reaction scheme: Fe3++ H2O2-->[Fe4+=O]R' (Compound I) + H2O [Fe4+=O]R' + substrate -->[Fe4+=O]R (Compound II) + oxidised substrate[Fe4+=O]R + substrate -->Fe3++ H2O + oxidised substrate In this mechanism, the enzyme reacts with one equivalent of H2O2to give [Fe4+=O]R' (compound I). This is a two-electron oxidation/reduction reaction where H2O2is reduced to water and the enzyme is oxidised. One oxidising equivalent resides on iron, giving the oxyferryl [] intermediate, while in many peroxidases the porphyrin (R) is oxidised to the porphyrin pi-cation radical (R'). Compound I then oxidises an organic substrate to give a substrate radical [].Haem peroxidases include two superfamilies: one found in bacteria, fungi, plants and the second found in animals. The animal peroxidases comprise a group of homologous proteins that differ markedly from the plant/fungal/bacterial peroxidases in primary, secondary and tertiary structure, but which share with them a common function. Animal peroxidases probably arose independently of the plant/fungal/bacterial peroxidase superfamily and most likely belong to a different gene family. The crystal structures of a number of these proteins show that the active sites of animal peroxidase and plant/fungal/bacterial peroxidases are remarkably similar []. Short Name:  Haem_peroxidase

5 Child Features

DB identifier Type Name
IPR002207 Family Plant ascorbate peroxidase
IPR000823 Family Plant peroxidase
IPR019791 Family Haem peroxidase, animal
IPR001621 Family Fungal ligninase
IPR000763 Family Catalase-peroxidase haem

3 Contains

DB identifier Type Name
IPR002016 Domain Haem peroxidase, plant/fungal/bacterial
IPR019793 Binding_site Peroxidases heam-ligand binding site
IPR019794 Active_site Peroxidase, active site

1 Cross References

Identifier
SSF48113

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004601 IPR010255
GO:0020037 IPR010255
GO:0006979 IPR010255
GO:0055114 IPR010255

4 Ontology Annotations

GO Term Gene Name
GO:0004601 IPR010255
GO:0020037 IPR010255
GO:0006979 IPR010255
GO:0055114 IPR010255

0 Parent Features

41071 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231472 D8RG06 PAC:15416848 Selaginella moellendorffii 321  
430498 D8T9L5 PAC:15420192 Selaginella moellendorffii 594  
135053 D8T9L4 PAC:15411204 Selaginella moellendorffii 149  
136759 D8TCB8 PAC:15419403 Selaginella moellendorffii 267  
136751 D8TCC3 PAC:15419394 Selaginella moellendorffii 137  
136749 D8TCE9 PAC:15419378 Selaginella moellendorffii 80  
137067 D8TCU7 PAC:15417021 Selaginella moellendorffii 330  
236822 D8TE02 PAC:15412077 Selaginella moellendorffii 310  
14687 D8RLX8 PAC:15412979 Selaginella moellendorffii 285  
231875 D8RLP7 PAC:15419884 Selaginella moellendorffii 312  
3741 D8RLX7 PAC:15415249 Selaginella moellendorffii 285  
96952 D8RLM9 PAC:15411669 Selaginella moellendorffii 347  
413062 D8RN80 PAC:15411482 Selaginella moellendorffii 306  
97402 D8RMR9 PAC:15410665 Selaginella moellendorffii 316  
97331 D8RMB1 PAC:15409914 Selaginella moellendorffii 332  
97201 D8RNF5 PAC:15409055 Selaginella moellendorffii 283  
138345 D8TF49 PAC:15422046 Selaginella moellendorffii 113  
28740 D8QVR3 PAC:15410235 Selaginella moellendorffii 128  
230146 D8QVR1 PAC:15411587 Selaginella moellendorffii 341  
39794 D8QVR2 PAC:15420444 Selaginella moellendorffii 50  
79034 D8QUT9 PAC:15421290 Selaginella moellendorffii 333  
101384 D8RT20 PAC:15402483 Selaginella moellendorffii 59  
101258 D8RT11 PAC:15401663 Selaginella moellendorffii 315  
101253 D8RT10 PAC:15401662 Selaginella moellendorffii 320  
232270 D8RT22 PAC:15418239 Selaginella moellendorffii 302  
232269 D8RT21 PAC:15418216 Selaginella moellendorffii 315  
414521 D8RT12 PAC:15418092 Selaginella moellendorffii 322  
232359 D8RUS5 PAC:15418990 Selaginella moellendorffii 336  
228326 D8RVX4 PAC:15406830 Selaginella moellendorffii 318  
415383 D8RVY4 PAC:15419641 Selaginella moellendorffii 180  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8062820
            7922023
            10403190