Protein Domain : IPR002207

Type:  Family Name:  Plant ascorbate peroxidase
Description:  Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. They are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, fungal, plant and bacterial peroxidases can be viewed as members of a superfamily consisting of 3 major classes. Class I, the intracellular peroxidases, includes yeast cytochrome c peroxidase (CCP), ascorbate peroxidase (AP) and bacterial catalase-peroxidases.In chloroplasts of higher plants, oxygen consumption in the absence of electron acceptors is accompanied by production of H2O2 and activated forms of oxygen. Chloroplasts contain several protective systems (such as superoxide dismutase (SOD), alpha-tocopherol and carotenoids), which are effective against various forms of activated oxygen. However, they lack catalase, and the disposal of H2O2 is accomplished by other means.Ascorbic acid is a strong antioxidant that is effective in scavenging superoxide (O2-'), hydroxyl (OH') radicals and singlet oxygen. It can also remove H2O2 in the following reaction:Ascorbate + H2O2 -->dehydroascorbate + 2 H2OAscorbate peroxidase (AP) is the main enzyme responsible for hydrogen peroxide removal in the chloroplasts and cytosol of higher plants.The 3D structure of pea cytosolic ascorbate peroxidase has an overall fold virtually identical to that of CCP []. The protein consists of 2 all-alpha domains, between which is embedded the haem group. The most pronounced difference between the AP and CCP structures is the absence of an antiparallel beta-hairpin between the G and H helices in the AP molecule. Short Name:  Asc_peroxidase

0 Child Features

3 Contains

DB identifier Type Name
IPR002016 Domain Haem peroxidase, plant/fungal/bacterial
IPR019793 Binding_site Peroxidases heam-ligand binding site
IPR019794 Active_site Peroxidase, active site

1 Cross References

Identifier
PR00459

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004601 IPR002207
GO:0020037 IPR002207
GO:0006979 IPR002207
GO:0055114 IPR002207

4 Ontology Annotations

GO Term Gene Name
GO:0004601 IPR002207
GO:0020037 IPR002207
GO:0006979 IPR002207
GO:0055114 IPR002207

1 Parent Features

DB identifier Type Name
IPR010255 Family Haem peroxidase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231472 D8RG06 PAC:15416848 Selaginella moellendorffii 321  
430498 D8T9L5 PAC:15420192 Selaginella moellendorffii 594  
137067 D8TCU7 PAC:15417021 Selaginella moellendorffii 330  
236822 D8TE02 PAC:15412077 Selaginella moellendorffii 310  
231875 D8RLP7 PAC:15419884 Selaginella moellendorffii 312  
97402 D8RMR9 PAC:15410665 Selaginella moellendorffii 316  
97331 D8RMB1 PAC:15409914 Selaginella moellendorffii 332  
230146 D8QVR1 PAC:15411587 Selaginella moellendorffii 341  
79034 D8QUT9 PAC:15421290 Selaginella moellendorffii 333  
101258 D8RT11 PAC:15401663 Selaginella moellendorffii 315  
101253 D8RT10 PAC:15401662 Selaginella moellendorffii 320  
266691 D8QY20 PAC:15409987 Selaginella moellendorffii 325  
104905 D8RZ04 PAC:15415754 Selaginella moellendorffii 328  
105029 D8RZB4 PAC:15411851 Selaginella moellendorffii 300  
232728 D8RYY2 PAC:15421834 Selaginella moellendorffii 296  
416327 D8RYY1 PAC:15422334 Selaginella moellendorffii 324  
106106 D8S101 PAC:15415519 Selaginella moellendorffii 325  
106421 D8S1P4 PAC:15417780 Selaginella moellendorffii 315  
177154 D8S5W1 PAC:15401895 Selaginella moellendorffii 326  
418626 D8S6M6 PAC:15408137 Selaginella moellendorffii 329  
81737 D8R0F6 PAC:15410621 Selaginella moellendorffii 319  
233332 D8S7T0 PAC:15421716 Selaginella moellendorffii 326  
233271 D8S756 PAC:15421070 Selaginella moellendorffii 355  
114366 D8SDJ5 PAC:15418458 Selaginella moellendorffii 315  
143155 D8R162 PAC:15413317 Selaginella moellendorffii 330  
421222 D8SEE2 PAC:15414301 Selaginella moellendorffii 308  
115216 D8SEE0 PAC:15420530 Selaginella moellendorffii 281  
179387 D8SFV7 PAC:15409355 Selaginella moellendorffii 324  
115982 D8SFT8 PAC:15403606 Selaginella moellendorffii 331  
421525 D8SFJ8 PAC:15416478 Selaginella moellendorffii 328  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7703247