Protein Domain : IPR015813

Type:  Domain Name:  Pyruvate/Phosphoenolpyruvate kinase-like domain
Description:  Pyruvate kinase controls the exit from the glysolysis pathway, catalysing the transfer of phosphate from phosphooenolpyruvate (PEP) to ADP. Mammalian pyruvate kinase is a homotetramer, where each polypeptide subunit consists of four domains: N-terminal, A domain, B domain and C-terminal. Activation of the enzyme is believed to occur via the clamping down of the B domain onto the A domain to dehydrate the active site cleft. The N- and C-terminal domains are situated at inter-subunit contact sites, and could be involved in assembly and communication within the complex. The N-terminal domain has a TIM beta/alpha-barrel structure. Homologous TIM-barrel domains are found in the following proteins:N-terminal of pyruvate kinase (), which is interrupted by an all-beta domain [].C-terminal of pyruvate phosphate dikinase (), which has a similar mode of substrate binding to pyruvate kinase [].Phosphoenolpyruvate carboxylase (); this domain has additional helices [].Phosphenolpyruvate mutase()/Isocitrate lyase (), where it forms a swapped dimer [].HpcH/HpaI aldolases, such as the beta subunit of citrate lyase, where it forms a swapped dimer, and contains a pyruvate kinase-type metal binding site [].Ketopantoate hydroxymethyltransferase PanB (), where a C-terminal helix exchange is observed in some enzymes []. Short Name:  Pyrv/PenolPyrv_Kinase-like_dom
Paste the following link

4 Child Features

DB identifier Type Name
IPR000121 Domain PEP-utilising enzyme, C-terminal
IPR015793 Domain Pyruvate kinase, barrel
IPR005000 Domain HpcH/HpaI aldolase/citrate lyase domain
IPR012698 Domain Phosphoenolpyruvate phosphomutase, core

3 Contains

DB identifier Type Name
IPR018523 Conserved_site Isocitrate lyase/phosphorylmutase, conserved site
IPR018129 Active_site Phosphoenolpyruvate carboxylase, active site
IPR018209 Active_site Pyruvate kinase, active site

2 Cross Referencess

Identifier
G3DSA:3.20.20.60
SSF51621

12 Found Ins

DB identifier Type Name
IPR006254 Family Isocitrate lyase
IPR001697 Family Pyruvate kinase
IPR003700 Family Ketopantoate hydroxymethyltransferase
IPR021135 Family Phosphoenolpyruvate carboxylase
IPR011206 Family Citrate lyase beta subunit-like
IPR007566 Family Phosphoenolpyruvate carboxylase, archaeal-type
IPR012695 Family 2-methylisocitrate lyase
IPR012697 Family Carboxyvinyl-carboxyphosphonate phosphorylmutase
IPR006475 Family Citrate lyase, beta subunit, bacteria
IPR012649 Family Phosphonopyruvate hydrolase
IPR012689 Family 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
IPR017648 Family 2-dehydro-3-deoxyglucarate aldolase, GarL

1 GO Annotation

GO Term Gene Name
GO:0003824 IPR015813

1 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR015813

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171246 D8RG97 PAC:15407293 Selaginella moellendorffii 559  
231516 D8RGC5 PAC:15417454 Selaginella moellendorffii 491  
404685 D8QW32 PAC:15411855 Selaginella moellendorffii 509  
148941 D8RQ18 PAC:15411683 Selaginella moellendorffii 1026  
173629 D8RRV3 PAC:15416293 Selaginella moellendorffii 358  
81343 D8QZ83 PAC:15407411 Selaginella moellendorffii 310  
111216 D8S8M2 PAC:15408756 Selaginella moellendorffii 940  
444504 D8SA75 PAC:15417319 Selaginella moellendorffii 270  
420727 D8SCX4 PAC:15415170 Selaginella moellendorffii 566  
115610 D8SEV5 PAC:15423460 Selaginella moellendorffii 975  
116243 D8SGH2 PAC:15423389 Selaginella moellendorffii 510  
234345 D8SK58 PAC:15402387 Selaginella moellendorffii 479  
230748 D8R4T7 PAC:15416165 Selaginella moellendorffii 897  
407118 D8R3Z0 PAC:15416548 Selaginella moellendorffii 423  
168147 D8R5U0 PAC:15419920 Selaginella moellendorffii 448  
139314 D8QPS6 PAC:15402642 Selaginella moellendorffii 514  
402546 D8QR09 PAC:15405012 Selaginella moellendorffii 741  
66137 D8RB99 PAC:15406134 Selaginella moellendorffii 273  
140876 D8QSY2 PAC:15409883 Selaginella moellendorffii 529  
447920 D8T3J3 PAC:15406805 Selaginella moellendorffii 966  
evm.model.supercontig_1.236 PAC:16404162 Carica papaya 515  
evm.model.supercontig_1.237 PAC:16404163 Carica papaya 696  
evm.model.supercontig_1.316 PAC:16404251 Carica papaya 479  
evm.model.supercontig_106.27 PAC:16405190 Carica papaya 531  
evm.model.supercontig_11.73 PAC:16405742 Carica papaya 355  
evm.model.supercontig_119.25 PAC:16406540 Carica papaya 510  
evm.model.supercontig_128.60 PAC:16407487 Carica papaya 460  
evm.model.supercontig_16.74 PAC:16410111 Carica papaya 904  
evm.model.supercontig_175.15 PAC:16411041 Carica papaya 348  
evm.model.supercontig_26.98 PAC:16415344 Carica papaya 321  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12906829
            11563914
            12467579
            11790099
            11526312
            7064730