Protein Domain : IPR011206

Type:  Family Name:  Citrate lyase beta subunit-like
Description:  This entry represents a group of proteins belonging to the HpcH/HpaI aldolase family. Proteins in this entry include citrate lyase subunit beta, malyl-CoA lyase and (3S)-malyl-CoA thioesterase. This entry also includes beta-methylmalyl-CoA lyase (rrnAC0690) from Haloarcula marismortui. Citrate lyase catalyses the magnesium-dependent cleavage of citrate to acetate and oxaloacetate. In bacteria, this reaction is involved in citrate fermentation. The bacterial enzyme is composed of three subunits: alpha, beta and gamma. Catalytic activity resides on the alpha- and beta-subunits, whereas the gamma-subunit serves as an acyl carrier protein (ACP) []. Mammalian citrate lyase beta proteins display similarity to the bacterial enzymes [].Malyl-CoA lyase catalyses the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA []. (3S)-malyl-CoA thioesterase catalyses the hydrolysis of (3S)-malyl-CoA to (3S)-malate and free CoA []. Haloarcula marismortui beta-methylmalyl-CoA lyase may be involved in the methylaspartate cycle []. It catalyses the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate with some (S)-malyl-CoA thioesterase activity []. Short Name:  Citrate_lyase_beta/mcl1/mcl2
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1 Child Features

DB identifier Type Name
IPR006475 Family Citrate lyase, beta subunit, bacteria

1 Contains

DB identifier Type Name
IPR015813 Domain Pyruvate/Phosphoenolpyruvate kinase-like domain

1 Cross References

Identifier
PIRSF015582

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30751.m000024 B9TFR8 PAC:16824593 Ricinus communis 306  
59498.m000013 B9TJP6 PAC:16829261 Ricinus communis 364  
Brdisv1pangenome1011543m.p PAC:33622371 Brachypodium distachyon Pangenome 295  
Brdisv1BdTR11A1040052m.p PAC:35691908 Brachypodium distachyon BdTR11a 295  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11741334
            10924139
            21252347
            15687206
            20047909