Protein Domain : IPR014209

Type:  Family Name:  RNA polymerase sigma-K type
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. The sporulation-specific transcription factor sigma-K (also called sigma-27) is expressed in the mother cell compartment of endospore-forming bacteria such as Bacillus subtilis. Like its close homologue sigma-E (sigma-29, see ), also specific to the mother cell compartment, it must be activated by a proteolytic cleavage.Note: that in B. subtilis (and apparently also in Clostridium tetani), but not in other endospore forming species such as Bacillus anthracis, the sigK gene is generated by a non-germline (mother cell only) chromosomal rearrangement that recombines coding regions for the N-terminal and C-terminal regions of sigma-K []. Short Name:  RNA_pol_sigma-K
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0 Child Features

6 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR013324 Domain RNA polymerase sigma factor, region 3/4
IPR013325 Domain RNA polymerase sigma factor, region 2
IPR007627 Domain RNA polymerase sigma-70 region 2
IPR007630 Domain RNA polymerase sigma-70 region 4
IPR000943 Domain RNA polymerase sigma-70

1 Cross References

Identifier
TIGR02846

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR014209
GO:0003700 IPR014209
GO:0016987 IPR014209
GO:0006352 IPR014209
GO:0006355 IPR014209

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR014209
GO:0003700 IPR014209
GO:0016987 IPR014209
GO:0006352 IPR014209
GO:0006355 IPR014209

1 Parent Features

DB identifier Type Name
IPR016263 Family RNA polymerase sporulation-specific sigma factor

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s92_50V3.1.p PAC:32963381 Physcomitrium patens 713  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189
            2163341