GO Term : GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO
Namespace:  biological_process Obsolete:  false
description  Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

56 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0004222 metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0008237 metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0008233 peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0070011 peptidase activity, acting on L-amino acid peptides Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0004175 endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0052547 regulation of peptidase activity Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0080090 regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0031323 regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0060255 regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

80 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
negatively regulates GO:1902945 GO:1902963
is_a GO:1902992 GO:1902963
is_a GO:1904684 GO:1902963
negatively regulates GO:1902945 GO:1902963
is_a GO:1902962 GO:1902963
is_a GO:0065007 GO:1902963
is_a GO:1902991 GO:1902963
is_a GO:0010466 GO:1902963
is_a GO:0048519 GO:1902963
regulates GO:0019538 GO:1902963
is_a GO:0031324 GO:1902963
regulates GO:0043170 GO:1902963
is_a GO:0031323 GO:1902963
is_a GO:0080090 GO:1902963
regulates GO:0016787 GO:1902963
negatively regulates GO:0006508 GO:1902963
is_a GO:0052547 GO:1902963
is_a GO:0051336 GO:1902963
is_a GO:0052548 GO:1902963
negatively regulates GO:0043170 GO:1902963
negatively regulates GO:0044260 GO:1902963
regulates GO:0003824 GO:1902963
negatively regulates GO:0003674 GO:1902963
regulates GO:0008237 GO:1902963
negatively regulates GO:0044267 GO:1902963
is_a GO:1904683 GO:1902963
regulates GO:0004175 GO:1902963
is_a GO:0010951 GO:1902963
regulates GO:0071704 GO:1902963
is_a GO:0051346 GO:1902963

89 Synonyms

Name Type
negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation synonym
negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism synonym
negative regulation of metalloendoprotease activity involved in APP catabolism synonym
negative regulation of metalloendoprotease activity involved in APP catabolic process synonym
negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process synonym
negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown synonym
negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation synonym
negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism synonym
negative regulation of metalloendoproteinase activity involved in APP catabolism synonym
negative regulation of metalloendoproteinase activity involved in APP catabolic process synonym
down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown synonym
down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism synonym
down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process synonym
down regulation of metalloendopeptidase activity involved in APP catabolic process synonym
down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation synonym
down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown synonym
down regulation of metalloendopeptidase activity involved in APP catabolism synonym
down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism synonym
down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process synonym
down regulation of metalloendoprotease activity involved in APP catabolic process synonym
down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation synonym
down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown synonym
down regulation of metalloendoprotease activity involved in APP catabolism synonym
down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism synonym
down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process synonym
down regulation of metalloendoproteinase activity involved in APP catabolic process synonym
down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation synonym
down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown synonym
down regulation of metalloendoproteinase activity involved in APP catabolism synonym
down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism synonym