GO Term : GO:0035228 negative regulation of glutamate-cysteine ligase activity GO
Namespace:  biological_process Obsolete:  false
description  Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

21 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016874 ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0016881 acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0004357 glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
GO:0016879 ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009892 negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044092 negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0051340 regulation of ligase activity Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
GO:0051352 negative regulation of ligase activity Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
GO:0035227 regulation of glutamate-cysteine ligase activity Any process that modulates the activity of glutamate-cysteine ligase.
GO:0035228 negative regulation of glutamate-cysteine ligase activity Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase.

31 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0035227 GO:0035228
is_a GO:0051352 GO:0035228
negatively regulates GO:0004357 GO:0035228
negatively regulates GO:0004357 GO:0035228
is_a GO:0065007 GO:0035228
is_a GO:0065007 GO:0035228
is_a GO:0008150 GO:0035228
regulates GO:0008152 GO:0035228
regulates GO:0008150 GO:0035228
regulates GO:0016879 GO:0035228
is_a GO:0065009 GO:0035228
regulates GO:0004357 GO:0035228
regulates GO:0003824 GO:0035228
negatively regulates GO:0003674 GO:0035228
negatively regulates GO:0016881 GO:0035228
is_a GO:0019222 GO:0035228
regulates GO:0016874 GO:0035228
is_a GO:0048519 GO:0035228
is_a GO:0051340 GO:0035228
is_a GO:0050790 GO:0035228
is_a GO:0009892 GO:0035228
negatively regulates GO:0016879 GO:0035228
negatively regulates GO:0016874 GO:0035228
regulates GO:0003674 GO:0035228
is_a GO:0043086 GO:0035228
negatively regulates GO:0008150 GO:0035228
negatively regulates GO:0008152 GO:0035228
is_a GO:0044092 GO:0035228
is_a GO:0050789 GO:0035228
negatively regulates GO:0003824 GO:0035228

4 Synonyms

Name Type
inhibition of glutamate-cysteine ligase activity synonym
downregulation of glutamate-cysteine ligase activity synonym
down-regulation of glutamate-cysteine ligase activity synonym
down regulation of glutamate-cysteine ligase activity synonym