Protein Domain : IPR020321

Type:  Family Name:  H/ACA ribonucleoprotein complex, subunit Gar1, archaea
Description:  H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. More than 100 mammalian H/ACA RNAs form an equal number of ribonucleoproteins (RNPs) by associating with the same four core proteins: Cbf5 (the Psi-synthase), Gar1, Nhp2 (L7Ae in archaea) and Nop10. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes [].Crystal structures of archaeal H/ACA protein complexes show how the same four proteins accommodate more than 100 distinct but related H/ACA RNAs []. The complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind. The smallest of these proteins, Nop10, has an essential role in the assembly and activity of these particles and binds directly to the Psi-synthase to form the minimal active enzyme in archaea. The complex interacts with snoRNAs, Nop10 acting as a molecular adaptor for guiding snoRNP assembly [].Archaeal Gar1 have been shown to increase the catalytic activity of Cbf5 in pseudouridylating tRNA []. Short Name:  H/ACA_rnp_Gar1_arc
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0 Child Features

0 Contains

1 Cross References

Identifier
PD064583

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0001522 IPR020321
GO:0042254 IPR020321
GO:0072588 IPR020321

3 Ontology Annotations

GO Term Gene Name
GO:0001522 IPR020321
GO:0042254 IPR020321
GO:0072588 IPR020321

1 Parent Features

DB identifier Type Name
IPR007504 Family H/ACA ribonucleoprotein complex, subunit Gar1/Naf1

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16943774
            16647858
            22993689
            18473479